Reference

Convenient synthesis of 2-azido-2-deoxy-aldoses by diazo transfer

Convenient synthesis of 2-azido-2-deoxy-aldoses by diazo transfer. Vasella, Andrea; Witzig, Christian; Chiara, Jose Luis; Martin-Lomas, Manuel (Org.-Chem. Inst., Univ. Zurich, Zurich CH-8057, Switz.). Helv. Chim. Acta, 74(8), 2073-7 (English) 1991. CODEN: HCACAV. ISSN: 0018-019X. 5505-63-5 and 66-84-2 are also in the experiment. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) Diazo transfer from trifluoromethanesulfonyl azide to 2-amino-2-deoxyglycoses constitutes a high-yielding, simple procedure for the prepn. of partially protected or unprotected 2-azido-2-deoxyaldose. Thus, the D-allosamine deriv. I gave 93% azidobenzylidenedeoxypyranoside II, while diazo transfer to D-glucosamine III, followed by acetylation, gave the azide IV in 74-91% yield. D-Mannosamine and D-galactosamine likewise underwent azidation in 65 and 70% yields resp. .

Hierarchically self-assembling linear-dendritic hybrid polymers for delivery of biologically active agents

All Rights Reserved. Hierarchically self-assembling linear-dendritic hybrid polymers for delivery of biologically active agents. Cunningham, Paula Hammond; Wood, Kris G.; Langer, Robert; Little, Steven (Massachusetts Institute of Technology, USA). PCT Int. Appl. WO 2007002663 A2 4 Jan 2007, 48pp., which DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization).Several substances with their cas registry numbers 918161-17-8 and 5505-63-5 may be metioned in this study. CODEN: PIXXD2. APPLICATION: WO 2006-US24964 22 Jun 2006. PRIORITY: US 2005-692916P 22 Jun 2005; US 2005-710572P 23 Aug 2005. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 37 A linear-dendritic hybrid polymer for encapsulating biol. active materials. The hybrid polymer includes a ligand for a predetd. target, a dendron, and a polyethylene glycol (PEG) chain linking the ligand to the dendron. .