Reference

Inhibition of growth and regression of a transplantable rat chondrosarcoma by three retinoids

Inhibition of growth and regression of a transplantable rat chondrosarcoma by three retinoids. Trown, P. W.; Buck, M. J.; Hansen, R. (Dep. Chemother., Hoffmann-La Roche Inc., Nutley, N. J., USA). Cancer Treat. Rep., 60(11), 1647-53 (English) 1976. CODEN: CTRRDO. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) An arom. analog of retinoic acid, Ro 10-1670 (all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonat etraenoic acid)(I) [55079-83-9], its ethyl ester (Ro 10-9359 [54350-48-0]), and ethyl amide (Ro 11-1430 [56281-36-8]) inhibited the growth of the rat chondrosarcoma. The inhibitions occurred over a range of tolerated doses. At the higher tolerated dose levels, regression of established tumors was obsd. All 3 compds. were active when administered i.p. for 2 or 4 weeks.In this experiment, several chemicals are used like 54350-48-0 and 56281-36-8 The ethyl ester, Ro 10-9359, and the ethyl amide, Ro 11-1430, were also active when administered for 4 weeks as dietary admixes. In the latter expts., both compds. were equally effective at tolerated doses, but Ro 11-1430 was less toxic than Ro 10-9359 at higher doses. .

Synergistic effect of retinoic acid on DNA synthesis by prostaglandin F2a stimulated Swiss 3T3 cells

Synergistic effect of retinoic acid on DNA synthesis by prostaglandin F2a stimulated Swiss 3T3 cells. Eschenbruch, M.; Otto, A. M.; Jimenez de Asua, L. (Friedrich Miescher-Inst., Basel CH-4002, Switz.). Horm. Defined Media, Lect. Posters Eur. Conf. Serum-Free Cell Cult., 1st, Meeting Date 1982, 107-10. Edited by: Fischer, Guenther; Wieser, R. J. Springer: Berlin, Fed. Rep. Ger. (English) 1983. CODEN: 50TEA4. DOCUMENT TYPE: Conference CA Section: 2 (Mammalian Hormones) Retinoic acid [302-79-4] and its analogs (13-cis-retinoic acid [4759-48-2], retinyl acetate [127-47-9], trimethylmethoxyphenyl acid [55079-83-9], arotinoid ethylamide [71441-29-7], and an arotinoid keto deriv.) enhanced the effect of PGF2a [551-11-1] and insulin [9004-10-8] on DNA formation and cell division by Swiss mouse 3T3 cells. This synergy was unaffected by PGE1 or PGE2. Indomethacin had no effect on the synergy of retinoic acid with PGF2a indicating that retinoic acid did not exert its effect by increasing prostaglandin synthesis. Possible explanations for the synergistic effect of retinoic acid are given.