Detail of "55134-13-9"

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Comparison of anticoccidial efficacy, resistance and tolerance of narasin, monensin and lasalocid in chicken battery trials

Comparison of anticoccidial efficacy, resistance and tolerance of narasin, monensin and lasalocid in chicken battery trials. Weppelman, R. M.; Olson, G.; Smith, D. A.; Tamas, T.; Van Iderstine, A. (Merck Sharp and Dohme Res. Lab., Rahway, N. J., USA). Poult. Sci., 56(5), 1550-9 (English) 1977. CODEN: POSCAL. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The anticoccidial efficacy, host tolerance, and projected resistance development of the three polyether antibiotics, monensin (I) [17090-79-8], narasin [55134-13-9], and lasalocid [25999-31-9] were compared. The efficacy of narasin against different coccidial strains paralleled that of I in as much as strains which were refractory to I were also refractory to narasin. In contrast, lasalocid easily controlled some strains which were not well controlled by either narasin or I and failed to control 1 strain readily controlled by these 2 antibiotics. In growing chicks, lasalocid at the projected use level of 75 ppm and narasin at an efficacious level of 100 ppm were both better tolerated than I at the recommended use level of 121 ppm. The frequency of mutants resistant to each of these polyether compds. was less than 8.6 .times. 10-9 per drug sensitive oocyst for onestrain of Eimeria tenella. This corresponds to less than 0.036 and 0.148 as frequent as mutants of this strain resistant to glycarbylamide or to amquinate, resp.

Ionophorous properties of narasin, a new polyether monocarboxylic acid antibiotic, in rat liver mitochondria

Ionophorous properties of narasin, a new polyether monocarboxylic acid antibiotic, in rat liver mitochondria. Wong, David T.; Berg, David H.; Hamill, Robert H.; Wilkinson, John R. (Lilly Res. Lab., Eli Lilly and Co., Indianapolis, Indiana, USA). Biochem. Pharmacol., 26(15), 1373-6 (English) 1977. CODEN: BCPCA6. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Narasin [55134-13-9] (6.6 .times. 10-8M) inhibited the ATPase [9000-83-3] activity of rat liver mitochondria and reversed the swelling and H+ release after induction of cation transport; narasin showed ionophorous activities with alkali metal cations, selectivity decreasing in the order Na+ > K+ = Rb+ > Cs+ > Li+. Narasin induced permeability of mitochondria to Tl+ and NH4+. Narasin inhibited 50% of the ATP hydrolysis activated by dinitrophenol, valinomycin-K+, and monazomycin-K+-NH4+ with IC50 values of 2.5, 200, and 13nM resp.; the corresponding values for monensin [17090-79-8] were 7, 750, and 45nM. Polyether monocarboxylic acid ionophores, such as narasin and monensin, may play an important role in ionophore-producing organisms as NH4+ carriers.