Reference

The binding of twelve cephalosporin antibiotics to human serum albumin as studied by fluorescence assay techniques

The binding of twelve cephalosporin antibiotics to human serum albumin as studied by fluorescence assay techniques. Csiba, Andras; Ludwig, Endre; Magyar, Tamas (Peterfy Sandor Utcai Teruleti Vezeto Korhaz, Budapest 1441, Hung.). Gyogyszereszet, 29(7), 251-4 (Hungarian) 1985. CODEN: GYOGAI. ISSN: 0017-6036. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The competitive binding of 12 cephalosporins to human serum albumin was studied with 1-anilinonaphthalene-8-sulfonic acid, using the fluorimetric method of P.-L. Hsu, et al. (1974). The binding strength increased in the order: cefotaxime [63527-52-6], cephaloridine [50-59-9], cephalexin [15686-71-2], cefuroxime [55268-75-2], cefamandole [34444-01-4], cefoperozone [62893-19-0], ceftazidime [72558-82-8], cefsulodin [52152-93-9], cefoxitin [35607-66-0], cefalotin [153-61-7], and Ro 13-9904 [74578-69-1]. The binding mechanism is discussed.

Comparative therapeutic effects of cefodizime and other cephalosporins in the treatment of experimentally induced pneumonia in mice

Comparative therapeutic effects of cefodizime and other cephalosporins in the treatment of experimentally induced pneumonia in mice.Some chemicals with cas registry numbers like 25953-19-9 and 69739-16-8 are also used. Klesel, N.; Limbert, M.; Seibert, G.; Winkler, I.; Schrinner, E. (Hoechst A.-G., Frankfurt, Fed. Rep. Ger.). Recent Adv. Chemother., Proc. Int. Congr. Chemother., 14th, Issue Antimicrobial Sect. 2, 943-4. Edited by: Ishigami, Joji. Univ. Tokyo Press: Tokyo, Japan. (English) 1985. CODEN: 55GNAX. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) The chemotherapeutic activity of cefodizime [69739-16-8] was compared to that of cefotaxime [63527-52-6], cefoperazone [62893-19-0], latamoxef [64952-97-2], cefuroxime [55268-75-2], and cefazolin [25953-19-9]. The test model used was exptl. pneumonia caused by Klebsiella Pneumoniae DT-S in mice. In the treatment of pneumonic mice, cefodizime was 2- to 20-times more active than cefotaxime and ~4- to 90-times more active than latamoxef. The other ref. compds. were inactive or slightly active. In studies on the bactericidal activity in vivo, cefodizime was more active than cefotaxime. The bactericidal effect obtained with the other cephalosporins tested were low. .