Detail of "55466-04-1"

CAS Number:
55466-04-1
Name:
a-L-Arabinopyranoside, (3b,16b,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-ylO-6-deoxy-a-L-mannopyranosyl-(1®2)-O-[O-b-D-glucopyranosyl-(1®6)-O-[b-D-xylopyranosyl-(1®2)]-b-D-glucopyranosyl-(1®3)]-
Superlist Name:
Jujuboside A
Molecular Structure:
Formula:
C₅₈H₉₄O₂₆
Molecular Weight:
1207.35
Synonyms:
O-6-Deoxy-a-L-mannopyranosyl-(1(r)2)-O-[O-b-D-glucopyranosyl-(1(r)6)-O-[b-D-xylopyranosyl-(1(r)2)]-b-D-glucopyranosyl-(1(r)3)]-(3b,16b,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl-a-L-arabinopyranoside;
Density:
1.50 g/cm³
Melting Point:
222-225 °C

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Reference

Inhibitory effect of jujuboside A on glutamate-mediated excitatory signal pathway in hippocampus: Inhibitory effect of jujuboside A on glutamate-mediated excitatory signal pathway in hippocampus. Zhang, Mu; Ning, Gangmin; Shou, Caihua; Lu, Yinjun; Hong, Dihui; Zheng, Xiaoxiang (Department of Biomedical Engineering, Zhejiang University, Hangzhou Yuquan, Peop. Rep. China). Planta Medica, 69(8), 692-695 (English) 2003 Georg Thieme Verlag. CODEN: PLMEAA. ISSN: 0032-0943. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Jujuboside A (JuA) is a main component of jujubogenin extd. from the seed of Ziziphus jujuba Mill var spinosa (Bunge) Hu ex H F Chou (Ziziphus), which is widely used in Chinese traditional medicine for the treatment of insomnia and anxiety. Previously, we reported the inhibitory effects of JuA on hippocampal formation in vivo and in vitro, the present study was carried out to examine the effects of JuA on glutamate (Glu)-mediated excitatory signal pathway in hippocampus. Microdialysis coupled with high-performance liq. chromatog. (HPLC) was used to monitor the changes of Glu levels in the hippocampus induced by penicillin sodium, or a mixt. of penicillin sodium and JuA. The results showed that penicillin increased the hippocampal Glu concn. (p < 0.01) and a high dose of JuA (0.1 g/L) significantly blocked penicillin-induced Glu release (p < 0.05). Moreover, the effect of JuA on intracellular Ca2+ changes after the stimulation by Glu was studied in cultured hippocampal neurons with confocal laser scanning microscope (CLSM). It was found that Glu (0. 56-86-0 and 55466-04-1 which are cas registry numbers of substances are two of reagents here.5 mM) induced an intracellular [Ca2+]i increase (p < 0.01), and JuA significantly inhibited the Glu-induced Ca2+ increase. The calmodulin (CaM) antagonist trifluoperazine (TFP) showed a similar inhibitory effect as JuA. These observations suggested that JuA has inhibitory effects on Glu-mediated excitatory signal pathway in hippocampus and probably acts through its anti-calmodulin action. .

Interaction between spin-labeled calmodulin and jujuboside A: Interaction between spin-labeled calmodulin and jujuboside A. Li, Yuan; Zhou, Yuxiang; Ou, Yaohua; Zhou, Xin (Dep. Biol. Sci. Biotechnol., Tsinghua Univ., Beijing 100084, Peop. Rep. China). Shengwu Huaxue Zazhi, 8(1), 67-72 (Chinese) 1992.In this article, certain chemicals are used. Some of their cas registry numbers are 55466-04-1 and 9025-82-5 CODEN: SHZAE4. ISSN: 1000-8543. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Jujuboside A, an effective component of Chinese herbal drug, inhibits the activity of calmodulin on cyclic nucleotide phosphodiesterase (PDE) noncompetitively. By labeling calmodulin with maleimide deriv., the interaction between CaM and jujuboside A was studied with ESR spectroscopy. The results indicated that a calmodulin mol. can bind at least 2 jujuboside A with high affinity. The binding of jujuboside A affects the environments of lysine residues of CaM (most probably Lys 75 and 94). It is like that jujuboside A binds to CaM through hydrophobic interaction. By comparing the structural features, inhibition function and binding regions of trifluoperazine with jujuboside A, a model for regulation of PDE by calmodulin is suggested. .

Detail of "55466-04-1"

a-L-Arabinopyranoside, (3b,16b,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-ylO-6-deoxy-a-L-mannopyranosyl-(1®2)-O-[O-b-D-glucopyranosyl-(1®6)-O-[b-D-xylopyranosyl-(1®2)]-b-D-glucopyranosyl-(1®3)]-

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CAS No.55466-04-1 Jujuboside A

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CAS No.55466-04-1 Jujuboside A

CAS No.55466-04-1 Jujuboside A

CAS No.55466-04-1 Jujuboside A

Reference