Reference

Relation between the structure of alliin analogs and their inhibitory effect on platelet aggregation

Relation between the structure of alliin analogs and their inhibitory effect on platelet aggregation. Liakopoulou-Kyriakides, M. (Eng. Sch., Aristotelian Univ. Thessaloniki, Thessaloniki, Greece). Phytochemistry, 24(7), 1593-4 (English) 1985. CODEN: PYTCAS. ISSN: 0031-9422. 539-86-6 which is the cas registry number of some chemical is mentioned. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Alliin analogs were synthesized and tested for their inhibitory activity on platelet aggregation. Only allicin (S-oxodiallyl disulfide) [539-86-6] had a strong inhibitory effect comparable to that of alliin [556-27-4], whereas all the other tested compds. had no inhibitory activity even at 10-3 M level. .

Pharmacokinetics of alliin in mice

Pharmacokinetics of alliin in mice. Chang, Junmin; Chen, Jian; Zhang, Lijing (College of Pharmacy, Xinjiang Medical University, Wulumuqi 830054, Peop. Rep. China). Yaowu Fenxi Zazhi, 23(4), 308-310 (Chinese) 2003 Yaowu Fenxi Zazhi Bianji Weiyuanhui. CODEN: YFZADL. ISSN: 0254-1793. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 63 A HPLC method for detn. of alliin (S-allyl-L-cysteine sulfoxide) concn. in mice plasma was developed and its pharmacokinetics in mice was studied using Kromasil ODS-1 column (5 mm, 4. 556-27-4 is the cas registry number. This chemical is also mentioned in this article.6 mm x 250 mm) with water as mobile phase and the detection 220 nm. The plasma samples were extd. with methanol. 5-Fluorouracil was used as the internal std. The calibration curve was linear over the range from 14.8 to 148.1 mg mL-1 with r 0.9992. The limit of detection was 0.06 mg mL-1, the mean recovery was 95%. The intra-day and inter-day RSD both were < 5%. After single dose of 400 mg kg-1 in mice pharmacokinetic parameters were estd. to be as follows: CL = 0.074 mg.min kg- 1, K12 = 0.185 min-1, K21 = 0.852 min-1, Ka = 0.476 min-1, t1/2VFa = 0.665 min, t1/2VFb = 27.246 min, AUC = 5 413.66 mg.min mL-1. This method was simple, precise and reliable and might be suitable for detn. of alliin in plasma. .