Reference

Effect of total parenteral nutrition on the nutritional status and immunocompetence in host and on the tumor growth

Effect of total parenteral nutrition on the nutritional status and immunocompetence in host and on the tumor growth. Nishijima, Muneyoshi; Ohyanagi, Harumasa; Saitoh, Yoichi (Sch. Med., Kobe Univ., Kobe, Japan). Nippon Geka Gakkai Zasshi, 85(7), 643-53 (Japanese) 1984. CODEN: NGGZAK. ISSN: 0301-4894. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 14, 15, 18 In rats with transplanted lung carcinoma, total parenteral nutrition resulted in accelerated tumor growth; thymidine kinase [9002-06-6] activity and mitotic index of the tumor was higher in these animals than in the low-calorie infusion group. Both the cellular and humoral immune systems were also more active in the well nourished rats. Although total parenteral nutrition had no effect on the chemotherapeutic efficacy of Adriamycin [23214-92-8] or ACNU [55661-38-6], the incidence of adverse effects from the antitumor drugs was lower and the survival rate after drug treatment was more favorable than in the low-calorie group.

Preparation of liposome-encapsulated antitumor drugs; relationship between lipophilicity of drugs and in vitro drug release

Preparation of liposome-encapsulated antitumor drugs; relationship between lipophilicity of drugs and in vitro drug release. Tsukada, Kazuhiro; Ueda, Seigo; Okada, Ryuzo (Prod. Dev. Lab., Sankyo Co., Ltd., Tokyo 140, Japan). Chem. Pharm. Bull., 32(5), 1929-35 (English) 1984. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Liposomal encapsulation of drugs by a reverse-phase evapn. vesicle method was carried out, and the relation between the in vitro release rates and the lipophilicity of drugs was investigated. Carboquone [24279-91-2], nimustine (ACNU) [42471-28-3], nimustine-HCl [55661-38-6], cytosine arabinoside [147-94-4], 5-fluorouracil [51-21-8] and related compds. were used as model drugs. Encapsulation of the drugs in liposomes had no relation with the partition coeffs. of the drugs, whereas the in vitro release rate was highly correlated to the partition coeff. Evidently, the drug was released more slowly when the partition coeff. was lower. Therefore, to achieve sustained release of a drug by means of liposomal encapsulation, it would be necessary to decrease the partition coeff. of the drug by converting it into the hydrochloride form, as in the case of ACNU, or by forming the Na salt of the drug if the drug has a carboxylic acid group.