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Detail of "557795-19-4"

  • CAS Number:
  • 557795-19-4
  • Name:

  • 1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-

  • Superlist Name:
  • Sunitinib
  • Molecular Structure:
  • Formula:
  • C22H27FN4O2
  • Molecular Weight:
  • 398.47
  • Synonyms:
  • SU-11248;Sunitinib base;N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide;N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-;(Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide;
  • Density:
  • 1.23 g/cm3
  • Melting Point:
  • 189-191 °C
  • Boiling Point:
  • 572.136 °C at 760 mmHg
  • Flash Point:
  • 299.818 °C
  • Appearance:
  • yellow solid
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N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

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Reference

Antitumor sustained-release microsphere injection formulationss containing angiogenesis inhibitors and bendamustine
All Rights Reserved. Antitumor sustained-release microsphere injection formulationss containing angiogenesis inhibitors and bendamustine. Kong, Qingxia (Jinan Shuaihua Pharmaceutical Science and Technology Co., Ltd., Peop. Rep. China). Faming Zhuanli Shenqing Gongkai Shuomingshu CN 1887267 A 3 Jan 2007, 30pp. (Chinese). (People's Republic of China). CODEN: CNXXEV. APPLICATION: CN 2010-200733 25 Jul 2006. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 The invention provides new antitumor sustained-release microsphere injection formulationss contg. angiogenesis inhibitors and bendamustine. The antitumor compn. is composed of (by wt.%) sustained-release microsphere comprising antitumor effective constituents of angiogenesis inhibitors and bendamustine 0.5-60, sustained-release adjuvant 40-99 and suspending agent 0.0-30, and solvent. The sustained-release adjuvant is selected from poly(lactic acid), poly(glycolic acid), p-carboxyphenoxypropane-sebacic acid copolymer, etc.In this experiment, several chemicals are used like 557795-19-4 and 252916-29-3 The suspending agent is selected from sodium CM-cellulose, sorbitol, tween, etc. The angiogenesis inhibitors are selected from marimastat, SU5416, SU6668, fumagillin, TNP-470, gefitinib, erlotinib, lapatinib, vatalanib, pelitinib, carboxyamidotriazole, thalidomide, linomide, angiostatin, endostatin, endostar, imatinib mesylate, semaxanib, dasatinib, avastin, canertinib, sorafenib, sunitinib, telcyta, panitumumab. The product can inhibit growth of tumor effectively, and enhance therapeutic effectiveness of non-operative treatment such as chemotherapy, etc. .
Antitumor sustained-release injection containing vascular inhibitor and cytotoxic drug
All Rights Reserved. Antitumor sustained-release injection containing vascular inhibitor and cytotoxic drug. Kong, Qingzhong; Yu, Jianjiang; Su, Hongqing (Shandong Lan-Jin Bioengineering Co., Ltd., Peop. Rep. China). Faming Zhuanli Shenqing Gongkai Shuomingshu CN 1850049 A 25 Oct 2006, 30pp. (Chinese). (People's Republic of China). CODEN: CNXXEV. APPLICATION: CN 2010-200542 9 Jun 2006. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 The sustained-release injection is comprised of (A) sustained-release microsphere comprising effective constituent 0.5-60, sustained-release adjuvant 40-99% and suspending agent 0.0-30.0%; and (B) solvent. The antitumor effective constituent is selected from vascular inhibitor and/or and cytotoxic drug. Said vascular inhibitor is selected from gefitinib, tarceva, lapatinib, angiostatin, avastin, canertinib, panitumumab, etc., or the mixt. thereof. Said cytotoxic drug is selected from one of camptothecin, procarbazine, taxol, cisplatin, carboplatin, chlorambucil, etc., or the mixt. thereof. The sustained-release adjuvant is selected from one of (a) polylactic acid; (b) Polyglycolic acid-hydroxyacetic acid copolymer; (c) polifeprosan; (d) ethene-vinyl acetate copolymer; (e) difatty acid-sebacic acid copolymer; (f) poly(erucic acid dimer-sebacic acid) copolymer; (g) poly(fumaric acid-sebacic acid) copolymer; (h) sodium CM-cellulose, hydroxypropyl cellulose, xylitol, oligosaccharide, chondroitin, chitin, hyaluronic acid, collagens, etc.; or (i) racemic polylactic acid, etc., or the mixt. thereof. The suspending agent is one of (a) 0.5-3.0 % (sodium) CM-cellulose; (b) 5-15 % mannitol; (c) 5-15 % sorbitol; (Crosslinked) 0.1-1.5 % surfactant; (e) 0.1-0.5 % tween 20; (f) (iodine) glycerin, dimethicone, propylene glycol, or carbomer; (g) 0.5-5 % sodium CM-cellulose + 0.1-0.5 % tween 80; (h) 5-20 % mannitol + 0. 15663-27-1 and 557795-19-4 which are cas registry numbers of substances are two of reagents here.1-0.5 % tween 80; or (i) 0.5-5 % sodium CM-cellulose + 5-20 % sorbitol + 0.1-0.5 % tween 80. The product can inhibit tumor cell and blood vessel, also can increase local concn. and enhance therapeutical effect. .
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