Reference

Isolation and identification of degradation products of betahistine hydrochloride in drug forms

Isolation and identification of degradation products of betahistine hydrochloride in drug forms. Erguven, H.; Carducci, C. N.; Barsic, G.; Gaozza, C. H. (Fac. Farm. Bioquim., Univ. Buenos Aires, Buenos Aires, Argent.). Rev. Farm. (Buenos Aires), 124(1-12), 33-4 (Spanish) 1982. CODEN: RFABAN. ISSN: 0034-9496. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) After subjecting betahistine-HCl (I-HCl) [5579-84-0] to degrdn. by a) sunlight, b) UV light, c) heating, d) heating with NaOH, e) heating with HCl, or f) H2O2, TLC anal. showed 2-(2-hydroxyethyl)pyridine [103-74-2], MeNH2 [74-89-5], 2-vinylpyridine [100-69-6], and betahistine N-oxide [88796-99-0] as degrdn. products.

Betahistine dihydrochloride interaction with the histaminergic system in the cat: neurochemical and molecular mechanisms

Betahistine dihydrochloride interaction with the histaminergic system in the cat: neurochemical and molecular mechanisms. Tighilet, Brahim; Trottier, Suzanne; Mourre, Christiane; Chotard, Carole; Lacour, Michel (UMR 6149 "Neurobiologie Integrative et Adaptative", Universite de Provence/CNRS, 52 Faculte de Saint Jerome-Case 361, Marseille F-13397, Fr.).Chemicals with cas numbers 5579-84-0 and 9024-61-7 also play role. European Journal of Pharmacology, 446(1-3), 63-73 (English) 2002 Elsevier Science B.V. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Drugs interfering with the histaminergic system facilitate behavioral recovery after vestibular lesion, likely by increasing histamine turnover and release. The effects of betahistine (structural analog of histamine) on the histaminergic system were tested by quantifying mRNA for histidine decarboxylase (enzyme synthesizing histamine) by in situ hybridization and binding to histamine H3 receptors (mediating, namely, histamine autoinhibition) using a histamine H3 receptor agonist ([3H]N-a-methylhistamine) and radioautog. methods. Expts. were done in brain sections of control cats (N=6) and cats treated with betahistine for 1 (N=6) or 3 (N=6) weeks. Betahistine treatment induced sym. changes with up-regulation of histidine decarboxylase mRNA in the tuberomammillary nucleus and redn. of [3H]N-a-methylhistamine labeling in both the tuberomammillary nucleus, the vestibular nuclei complex and nuclei of the inferior olive. These findings suggest that betahistine upregulates histamine turnover and release, very likely by blocking presynaptic histamine H3 receptors, and induces histamine H3 receptor downregulation. This action on the histaminergic system could explain the effectiveness of betahistine in the treatment of vertigo and vestibular disease. .