Reference

Mechanism of the therapeutic effect of anisodamine in disseminated intravascular coagulation: study of platelet adhesion and aggregation, malondialdehyde, thromboxane B2, 6-ketoprostaglandin F1a, and microcirculation

Mechanism of the therapeutic effect of anisodamine in disseminated intravascular coagulation: study of platelet adhesion and aggregation, malondialdehyde, thromboxane B2, 6-ketoprostaglandin F1a, and microcirculation. Zhang, Shu; Chang, Aimin; Li, Cifen; Li, Zhenjia; Yin, Zhongjian; Zhao, Xiu; Liang, Sulan (Cent. Res. Lab., PLA Gen. Hosp., Beijing, Peop. Rep. China). Exp. Hematol. (N. Y.), 15(1), 65-71 (English) 1987. CODEN: EXHMA6. ISSN: 0301-472X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In rabbits with disseminated intravascular coagulation (DIC), the presence of microthrombi in the microvasculature was noted. After treatment with anisodamine [55869-99-3], the prothrombin time stayed in the normal range, fibrinogen consumption was lessened, ADP-induced platelet aggregation was inhibited, thromboxane B2 and malondialdehyde concns. were lower than in the control group, and the elevation of 6-keto-PGF1a was prevented. Thus, the anti-platelet-aggregating, microcirculation-facilitating, thromboxane B2-inhibiting, malondialdehyde-inhibiting, and 6-keto-PGF1a-sparing effects of anisodamine are important mechanisms of its dramatic therapeutic effect on DIC.

The interaction of anisodamine with phospholipid membranes

The interaction of anisodamine with phospholipid membranes. Wang, Sumin; Huang, Fen; Fu, Yazhen; Zhang, Zhenglian; Dong, Renjie; Hu, Cuiqing (Inst. Biophys., Acad. Sin., Beijing, Peop. Rep. China). Kexue Tongbao (Foreign Lang. Ed.), 29(4), 529-32 (English) 1984. CODEN: KHTPBU. ISSN: 0454-0948. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The interaction of anisodamine (I) [55869-99-3] with dipalmitoyl phosphatidylcholine (DPPC) [2644-64-6] and dipalmitoyl phosphatidic acid (DPPA) [19698-29-4] liposomes is described as a trigger mechanism. I shifted the gel-liq. crystal phase transition of DPPC and DPPA to lower temps. Then the molar ratio of I and DPPA was , the transition temp. When the molar ratio of I and DPPA was , the transition temp. T1 of the peak in the higher temp. region showed a decrease of 10° K, while the same drug:DPPC molar ratio caused only a 1°-K decrease in temp. Furthermore, a phase sepn. was seen in the I-DPPA phase transition profile.