Detail of "5587-42-8"

Reference

Procedure for the production of N,N'-Carbonyldiazole from azolide salts

Procedure for the production of N,N'-Carbonyldiazole from azolide salts. Scherer, Johannes; Klausener, Alexander; Soellner, Robert (Bayer A.-G., Germany). Ger. Offen. DE 10035011 A1 31 Jan 2002, 8 pp. (German). (Germany). CODEN: GWXXBX. CLASS: ICM: C07D233-60. ICS: C07D235-08; C07D231-12; C07D231-56; C07D249-08; C07D249-18. APPLICATION: DE 2000-10035011 19 Jul 2000. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) N,N'-Carbonyldiazoles I [X1, X2, X3 = CR1, N; R1 = H, C1-6-alkyl; R2 = H; R1R2 = CH:CHCH:CH] are obtained in a particularly advantageous way, if one converts appropriate azolide salts, e.g., II [M = alkali metal, ammonium ion, phosphonium ion], with phosgene in aroms. or a ether as solvent and characterized by the azolide salts II being preferably made in a new procedure from an azole II [M = H], which one converts with a compd., M'R7 [M' = alkali metal, ammonium ion, phosphonium ion; R7 = alkyl, alkoxy, dialkylamino, HCO3] or MgR8Z ' [R8 = C1-6-alkyl, Ph; Z' = Cl, Br, I], in the presence of a solvent. Thus, carbonyldiazole III, was prepd. in 87% yield from imidazole, via reaction in PhCl with aq. NaOH followed by reaction with phosgene in the presence of tributylhexadecylphosphonium bromide. Keywords carbonyldiazole prepn azole salt formation condensation phosgene azolide prepn condensation phosgene Index Entries Heterocyclic compounds carbonyldiazoles; prepn. of N,N'-carbonyldiazoles from from azoles via azolide salts Heterocyclic compounds nitrogen, five-membered; prepn. of N,N'-carbonyldiazoles from from azoles via azolide salts Phase transfer catalysts Alkali metal compounds prepn. of N,N'-carbonyldiazoles from from azoles via azolide salts 57-09-0 80-73-9 1643-19-2 2751-90-8 4559-86-8 14937-45-2 108-90-7, uses 75-44-5 124-41-4 288-32-4, reactions 1073-32-1 1310-73-2, reactions 20671-53-8 40958-82-5 41253-21-8 55986-39-5 5587-42-8 530-62-1 14667-54-0 37868-93-2 41864-22-6 prepn. of N,N'-carbonyldiazoles from from azoles via azolide salts

N-[(1H-Imidazol-1-yl)alkyl]-1H-indolecarboxamides useful as thromboxane synthetase inhibitors and antihypertensive agents

N-[(1H-Imidazol-1-yl)alkyl]-1H-indolecarboxamides useful as thromboxane synthetase inhibitors and antihypertensive agents. Wright, William B., Jr.; Press, Jeffery B. (American Cyanamid Co.Chemical with cas number 106876-29-3 also plays role., USA). U.S. US 4619941 A 28 Oct 1986, 9 pp. (United States of America) CODEN: USXXAM. CLASS: ICM: A61K031-415. ICS: C07D403-12. NCL: 514397000. APPLICATION: US 84-673066 19 Nov 1984. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 The title compds. I (R1 = H, halo, C1-3 alkyl or alkoxy; R2 = H, C1-3 alkyl, PhCH2; R3, R4 = H, C1-3 alkyl, Ph; n = 2-8) and their pharmaceutically acceptable acid addn. salts were prepd. Addn. reaction of imidazole with H2C:CHCN at 100° over 3 h and subsequent hydrogenation of the product in MeOH over Raney Ni gave 1H-imidazole-1-propanamine which, as the di-HCl salt, amidated 1-methylindole-2-carboxylic acid in the presence of 1,1'-carbonyldiimidazole in THF to give I (R1 = R3 = R4 = H, R2 = Me, n = 3) (II). Rats with av. mean arterial blood pressure (MABP) of 160 ± 1.5 mm were treated with 100 mg II/kg. After 28 h, the MABP was 114 mm. .