CAS No.5593-20-4,Betamethasone 17,21-dipropionate Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	5593-20-4
Name:	Betamethasone 17,21-dipropionate
Article Data:	5

Formula:	C₂₈H₃₇FO₇
Molecular Weight:	504.596
Synonyms:	Pregna-1,4-diene-3,20-dione,9-fluoro-11b,17,21-trihydroxy-16b-methyl-, 17,21-dipropionate (7CI,8CI);Diproderm;Diprolene;Diprosis;Diprosone;Maxivate;Psorion;Rinderon DP;S3440;Sch 11460;b-Methasone 17,21-dipropionate;Halometasone Monohydrate;Pregna-1,4-diene-3,20-dione,9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11b,16b)-;
EINECS:	227-005-2
Density:	1.24 g/cm³
Melting Point:	178 °C
Boiling Point:	603.2 °C at 760 mmHg
Flash Point:	318.6 °C
Appearance:	Powder
Safety:	22-24/25
PSA:	106.97000
LogP:	3.81750

Synthetic route

: 378-44-9
betamethasone

: 5593-20-4
betamethasone dipropionate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / tetrahydrofuran / 2 h / 15 - 20 °C / Inert atmosphere 2: aluminum (III) chloride / 16.5 h / 10 - 30 °C 3: tetrahydrofuran; water / 8 h / 50 - 80 °C / 450.05 Torr View Scheme

: 5534-13-4
Betamethasone propionate

: 5593-20-4
betamethasone dipropionate

Conditions

Conditions	Yield
In tetrahydrofuran; water at 50 - 80℃; under 450.045 Torr; for 8h;

: 5593-20-4
betamethasone dipropionate

: 65669-64-9
17α,21-dihydroxy-9α-fluoro-16β-methylpregna-1,4,11(12)-triene-3,20-dione 17,21-dipropionate

Conditions

Conditions	Yield
With (diethylamido)sulfur trifluoride In dichloromethane for 16h; Ambient temperature;	93%

P2 S5: P2 S5

: 5593-20-4
betamethasone dipropionate

: 9α-Fluoro-16β-methyl-11,17,21-trihydroxypregna-1,4-dien-20-one-3-thione 17,21-dipropionate

Conditions

Conditions	Yield
In toluene	60%

: 5593-20-4
betamethasone dipropionate

: 72559-81-0
9α-fluoro-6β,11β,17α,21-tetrahydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 17,21-dipropionate

Conditions

Conditions	Yield
With selenious acid In 1,4-dioxane at 100℃; for 72h;	44.2%
With selenium(IV) oxide In 1,4-dioxane at 110℃; for 2.5h;	25%
Multi-step reaction with 2 steps 1: pyridine / 18 h / 60 °C 2: oxygen / CHCl3 / 3 h View Scheme

: 5593-20-4
betamethasone dipropionate

A: 378-44-9
betamethasone

B: 5534-13-4
Betamethasone propionate

C: 24703-00-2
6β-hydroxybetamethasone

D: 78144-00-0
6β-hydroxybetamethasone 17-propionate

Conditions

Conditions	Yield
With phosphate buffer; air; plasma of 20 d pregnant Sprague-Dawley rat at 37℃; for 1h; Product distribution; metabolism with tissues (plasma, liver, brain, placenta) from mothers and fetuses of Sprague-Dawley rats sacrificed on day 20 of pregnancy and mice on day 17 of pregnancy, further in vivo;	A 14.8 % Chromat. B 67.8 % Chromat. C 1.4 % Chromat. D 2.3 % Chromat.

...Expand

: 5593-20-4
betamethasone dipropionate

: 5534-13-4
Betamethasone propionate

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 6h; Ambient temperature;

: 5593-20-4
betamethasone dipropionate

: 98-88-4
benzoyl chloride

: 82926-64-5
9α-fluoro-3,11β,17α,21-tetrahydroxy-16β-methyl-1,3,5-pregnatriene-20-one 3-benzoate 17,21-dipropionate

Conditions

Conditions	Yield
In pyridine at 60℃; for 18h;

: 5593-20-4
betamethasone dipropionate

A: 378-44-9
betamethasone

B: 5534-13-4
Betamethasone propionate

C: betamethasone 21-monopropionate

Conditions

Conditions	Yield
With sulfuric acid In acetonitrile at 20℃; for 20h; Product distribution; Further Variations:; Temperatures;

...Expand

: 5593-20-4
betamethasone dipropionate

A: (Z)-betamethasone 20-hydroxy-17(20)-en-21-aldehyde

B: (E)-betamethasone 20-hydroxy-17(20)-en-21-aldehyde

Conditions

Conditions	Yield
With sodium hydroxide In acetonitrile at 20℃; for 0.333333h; Mattox rearrangement;	A 30 % Chromat. B 10 % Chromat.
With sodium hydroxide In water; acetonitrile at 20℃; for 0.333333h; Mattox rearrangement;

Downstream Products

78144-00-0

5534-13-4

378-44-9

Total:226 Page 1 of 6 1 2 3 4 5 6 Next>>

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Chemistry

IUPAC Name: [2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-Fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate
Molecular Weight: 504.587583 [g/mol]
Molecular Formula: C₂₈H₃₇FO₇
XLogP3: 3.6
H-Bond Donor: 1
H-Bond Acceptor: 8
EINECS: 227-005-2
Product Categories: Biochemistry; Hydroxyketosteroids; Steroids
refractive index: 69 °(C=1, Dioxane)
Water Solubility: 0.724 mg/L at 25 °C
Index of Refraction: 1.549
Molar Refractivity: 128.66 cm³
Molar Volume: 403.9 cm³
Surface Tension: 49.1 dyne/cm
Density: 1.24 g/cm³
Flash Point: 318.6 °C
Enthalpy of Vaporization: 102.93 kJ/mol
Boiling Point: 603.2 °C at 760 mmHg
Vapour Pressure: 4.58E-17 mmHg at 25 °C
Melting Point: 178 °C
Classification Code of Betamethasone dipropionate (CAS NO.5593-20-4): Anti-Inflammatory Agents; Drug / Therapeutic Agent; Glucocorticoid; Hormone; Reproductive Effect

Uses

Betamethasone dipropionate (CAS NO.5593-20-4) is applied as a topical cream, ointment, lotion or gel (Diprolene) to treat itching and other minor skin conditions such as eczema.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	103mg/kg (103mg/kg)		Drugs in Japan Vol. 6, Pg. 753, 1982.
mouse	LD50	oral	> 5gm/kg (5000mg/kg)	BEHAVIORAL: ANTIPSYCHOTIC SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
mouse	LD50	subcutaneous	78100ug/kg (78.1mg/kg)		Drugs in Japan Vol. 6, Pg. 753, 1982.
rat	LD50	intraperitoneal	> 4gm/kg (4000mg/kg)		Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
rat	LD50	oral	> 4gm/kg (4000mg/kg)		Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
rat	LD50	subcutaneous	> 4gm/kg (4000mg/kg)		Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.

Safety Profile

Safety Statements: 22-24/25
22:Do not breathe dust
24/25:Avoid contact with skin and eyes
WGK Germany: 2
RTECS: TU4058000
Poison by subcutaneous and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F⁻.

Specification

Betamethasone dipropionate (CAS NO.5593-20-4), its Synonyms are 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate ; Alphatrex ; Betamethasone 17,21-dipropionate ; Diproderm ; Diprolene ; Diprolene AF ; Diprosis ; Diprosone ; Maxivate ; Psorion ; Rinderon DP ; beta-Methasone 17,21-dipropionate ; Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-beta-methyl-, 17,21-dipropionate ; Pregna-1,4-diene-3,20-dione, 9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11beta,16beta) .