Reference

Compounds useful in reducing or preventing damage to the liver by alcohol

Compounds useful in reducing or preventing damage to the liver by alcohol. (Alcoholism and Drug Addiction Research Foundation, Can.). Belg. BE 837643 14 May 1976, 12 pp. (Unavailable). (Belgium). CODEN: BEXXAL. CLASS: IC: A61K.Several substances with their cas registry numbers 51678-08-1 and 51482-41-8 may be metioned in this study. PRIORITY: GB 75-2187 17 Jan 1975. DOCUMENT TYPE: Patent CA Section: 4 (Toxicology) Section cross-reference(s): 1 Alkyl derivs. of thiouracils and dithiouracils, capable of reducing hepatic thyroxine fixation and(or) decreasing conversion of thyroxine into triiodothyronine in the liver, are suggested as useful in treatment of EtOH [64-17-5]-induced liver damage. Prepn. methods for 6 such compds., 6-methyl-2-thiouracil [56-04-2], 6-methyl-2-thiouracil-5-acetic acid [62214-19-1], 6-methyl-2-thiouracil-5-propionic acid [945-12-0], 5-n-propyl-6-methyl-2-thiouracil [51482-41-8], 6-n-propyl-2,4-dithiouracil [51678-08-1], and an androstanyl deriv. are given. .

Determination of methylthiouracil in thyroid gland and meat of cattle by high-performance thin-layer chromatography

Determination of methylthiouracil in thyroid gland and meat of cattle by high-performance thin-layer chromatography. Pochard, M. F.; Karageorgis, M.; Chevalier, M. (Lab. Cent. Hyg. Aliment., Serv. Vet., Paris 75015, Fr.). Analusis, 11(10), 499-502 (French) 1983. CODEN: ANLSCY. ISSN: 0365-4877. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) A simple routine procedure is described for the detection of methylthiouracil [56-04-2] residues in thyroid gland and meat of adult slaughter cattle at levels as low as 30 ppb. After extn. with EtOAc and washing with petroleum ether, the ext. is cleaned up on polar Sep-pak column and analyzed by high-performance thin-layer chromatog. before and after derivatization with NBD-chloride with UV detection at 254 nm and 366 nm, resp.