Detail of "56-24-6"

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Tin distribution in adult rat tissues after exposure to trimethyltin and triethyltin

Tin distribution in adult rat tissues after exposure to trimethyltin and triethyltin. Cook, Larry L.; Stine, Karen E.; Reiter, Lawrence W. (Health Effects Res. Lab., Environ. Prot. Agency, Research Triangle Park, NC 27711, USA). Toxicol. Appl. Pharmacol., 76(2), 344-8 (English) 1984. CODEN: TXAPA9. ISSN: 0041-008X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The time course of distribution of Sn in the adult rat was detd. in brain, liver, kidneys, heart, and blood following single i.p. administrations of trimethyltin hydroxide (TMT) [56-24-6] and triethyltin bromide (TET) [2767-54-6]. Adult Long-Evans rats were killed 1, 4, 12, and 24 h, and at 5, 10, or 22 days following injection of TMT and TET, and tissues were analyzed for total Sn. TET exposure resulted in higher Sn concns. in brain, liver, and kidney tissues, whereas the 2 trialkyltins resulted in approx. equal Sn concns. in the heart and blood. Rates of elimination of Sn (expressed as elimination rate consts., Kel) were greater in all tissues following TET exposure than following TMT exposure. The concn. of Sn in the brain 12 h after TMT exposure was 4.4, 8.5, and 12.7 ng Sn/mg protein for dosages of 3.0, 6.0, and 9.0 mg/kg, resp. Sn was evenly distributed across the cerebellum, medulla-pons, hypothalamus, hippocampus, and striatum following TMT exposure. Thus, major differences occurred in the disposition and rates of elimination of Sn from body tissue after TMT and TET exposure.

Distribution of tin in brain subcellular fractions following the administration of trimethyltin and triethyltin to the rat

Distribution of tin in brain subcellular fractions following the administration of trimethyltin and triethyltin to the rat. Cook, Larry L.; Heath, Stacey M.; O'Callaghan, James P. (Health Eff. Res. Lab., U. S. Environ. Prot. Agency, Research Triangle Park, NC 27711, USA). Toxicol. Appl. Pharmacol., 73(3), 564-8 (English) 1984. CODEN: TXAPA9. ISSN: 0041-008X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The time course of Sn distribution in homogenates and subcellular fractions of rat brain was detd. following the acute administration of trimethyltin hydroxide (TMT) [2767-54-6] and triethyltin bromide (TET) [56-24-6] to the rat. Exposure to TMT resulted in lower concns. but greater persistence of Sn in subcellular fractions compared to exposure to TET. A delayed accumulation of Sn in the mitochondrial fraction was obsd. following the administration of TMT but not TET. Anal. of total protein and mitochondrial markers did not reveal differences between the compns. of mitochondrial fractions prepd. from control and TMT-treated rats.