Detail of "5611-51-8"

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Effects of systemic glucocorticoids on the degradation of glycosaminoglycans in the mandibular condylar cartilage of newborn mice

Effects of systemic glucocorticoids on the degradation of glycosaminoglycans in the mandibular condylar cartilage of newborn mice. Weiss, Anna; Raz, Esther; Silbermann, Michael (Fac. Med., Technion-Israel Inst. Technol., Haifa 31096, Israel). Bone Miner., 1(4), 335-46 (English) 1986. CODEN: BOMIET. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 13 The early in vivo effects of triamcinolone hexacetonide [5611-51-8], a potent fluorinated analog of cortisol [50-23-7], on the degrdn. of sulfated proteoglycans were examd. in condylar cartilage of newborn mice. While detg. the rate of [35S]sulfate release in test and control specimens, it became evident that in hormone-treated animals there was a dose-dependent retardation of the isotope clearance. Further, triamcinolone increased the half-life of condylar glycosaminoglycans (GAGs) from 16 h in control animals to 31.4 h in hormone-treated ones. Dexamethasone [50-02-2], another fluorinated analog of cortisol, and progesterone [57-83-0] evoked a similar effect. On the other hand, hydrocortisone and cortisone [53-06-5] induced a much milder effect, whereas the non-glucocorticoid steroid deoxycorticosterone did not affect the turnover of radiosulfate in this tissue. Clearance of the isotope from the serum was faster in the hormone-treated animals. The hormones led to a decrease in the overall content of GAGs, a feature that lasted for 24 h. Concomitant with their inhibitory effects on proteoglycan synthesis in cartilage, the glucocorticoids also induce a transient depressive effect on the degrdn. of proteoglycans and thereby interfere with the normal growth and development of this cartilage.

Involvement of glucocorticoids in cartilage growth and metabolism

Involvement of glucocorticoids in cartilage growth and metabolism. Silbermann, Michael; Weiss, Anna; Maor, Gila; Lewinson, Dina (Fac. Med., Technion-Israel Inst. Technol., Haifa, Israel). Adv. Exp. Med. Biol., 171(Glucocorticoid Eff. Their Biol. Consequences), 257-67 (English) 1984. CODEN: AEMBAP. ISSN: 0065-2598. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The effects of triamcinolone hexacetonide (I) [5611-51-8] (0.08-10 mg/kg, i.p.) on the growth and metab. of cartilage of the mandibular condyles of 4-day-old mice were studied at 0-144 h after treatment. Condylar wet wt. did not decrease until 120 h after I treatment. I caused a decrease in DNA content during the initial 24 h, but not thereafter; a redn. in the rate of [3H]thymidine uptake at 24 h and 144 h after treatment; and a lower RNA/DNA ratio in I-treated condyles throughout the exptl. period. I induced a pronounced redn. in the size of the proliferative and chondroblastic zones, whereas the progenitor and hypertrophic zones increased in size. I also led to a marked derangement of the internal organization of the condylar cartilage. I possessed a marked stimulatory effect on 45Ca2+ uptake, which was dose dependent, increased during the 1st 3 days after treatment, and rapidly declined thereafter. The incorporation of 35SO42- into TCA-insol. material was retarded by I in a dose-dependent and transitory manner. Statistical anal. suggests a correlation between these metabolic observations and the structural modifications.