Reference

Interactions of the UVRABC endonuclease in vivo and in vitro with DNA damaged by antineoplastic anthracyclines

Interactions of the UVRABC endonuclease in vivo and in vitro with DNA damaged by antineoplastic anthracyclines. Kacinski, Barry M.; Rupp, W. Dean (Sch. Med., Yale Univ., New Haven, CT 06510, USA). Cancer Res., 44(8), 3489-92 (English) 1984. CODEN: CNREA8. ISSN: 0008-5472. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The anthracycline antineoplastic agents adriamycin [23214-92-8] and N-trifluoroacetyladriamycin 14-valerate [56124-62-0] were assayed in vivo and in vitro for ability to produce DNA lesions recognized by the UVRABC endonuclease [81611-73-6], a DNA repair enzyme of Escherichia coli which recognizes large, bulky lesions in DNA. While both drugs produced DNA lesions, only the lesions produced by adriamycin were toxic to the E. coli. Hence, anthracycline antineoplastic activity may be related to prodn. of large, bulky lesions in DNA, while toxicity may correlate with toxicity measured in a simple E. coli DNA repair mutant test system.

Antitumor activity of N-trifluoroacetyladriamycin-14-valerate

Antitumor activity of N-trifluoroacetyladriamycin-14-valerate. Pratesi, G.; Casazza, A. M.; Di Marco, A. (Div. Exp. Oncol. B, Ist. Naz. Stud. Cura Tumor, Milan, Italy). Cancer Treat. Rep., 62(1), 105-10 (English) 1978. CODEN: CTRRDO. ISSN: 0361-5960. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The antitumor activity and toxicity of AD 32 (N-trifluoroacetyladriamycin 14-valerate)(I) [56124-62-0] dissolved in 10% Tween 80 in distd. water were compared to those of Adriamycin dissolved in distd. water or in 10% Tween 80 in distd. water, in mice bearing L1210 leukemia, P388 leukemia, Gross leukemia, and solid Sarcoma 180. Treatments were performed i.p. or i.v. according to different schedules. The antitumor activity of I was not superior to that of Adriamycin. The antitumor activity of Adriamycin dissolved in aq. soln. of Tween 80 was higher than that of Adriamycin dissolved in distd. water after i.v. treatment.