Detail of "56296-78-7"

CAS Number:
56296-78-7
Name:
Benzenepropanamine,N-methyl-g-[4-(trifluoromethyl)phenoxy]-,hydrochloride (1:1)
Superlist Name:
Fluoxetine hydrochloride
Molecular Structure:
Formula:
C₁₇H₁₈F₃NO^.HCl
Molecular Weight:
345.79
Deleted CAS:
59333-67-4
Synonyms:
Methyl[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amine hydrochloride;
EINECS:
260-101-2
Melting Point:
158-159 °C
Boiling Point:
395.1 °C at 760 mmHg
Flash Point:
192.8 °C
Appearance:
White to off-white powder
Hazard Symbols:
Xn
Risk Codes:
22-38-41
Safety:
26-36/37/39 Details
Transport Information:
UN 3249

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Reference

On the selective inhibition of serotonin uptake in vivo by ORG 6582: On the selective inhibition of serotonin uptake in vivo by ORG 6582. Sugrue, Michael F.; Goodlet, Ian; Mireylees, Stewardt E. (Dep. Pharmacol., Organon Lab. Ltd., Newhouse/Lanarkshire, Scot.). Eur. J. Pharmacol., 40(1), 121-30 (English) 1976. CODEN: EJPHAZ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In vivo blockade of serotonin (5-HT) [50-67-9] uptake was studied by investigating the effect of drug pretreatment on the ability of p-chloroamphetamine to lower rat brain 5-HT levels. Org 6582 (I) [59905-71-4] was .apprx.2-fold more potent than fluoxetine-HCl [56296-78-7], 5-fold more potent than chlorimipramine-HCl [17321-77-6],and 14-fold more potent than desipramine-HCl [58-28-6] in blocking the ability of p-chloroamphetamine to lower rat brain 5-HT content. I also had a longer duration of action than either fluoxetine or chlorimipramine. Although I did not effect amine steady state levels, it did decrease rat brain 5-HT turnover and lower rat brain levels of 5-hydroxyindoleacetic acid [54-16-0]. In contrast to both desipramine and chlorimipramine, I was devoid of effect on the ability of 1-metaraminol and 6-hydroxydopamine to lower rat heart noradrenaline (NA) levels. The ability of intraventricularly administered 6-hydroxydopamine to lower rat brain NA levels was unaltered by I pretreatment. The corresponding i.p. ED50 values for desipramine and chlorimipramine were 7.3 and 28.8 mg/kg, resp. Like desipramine and chlorimipramine, I had no effect on the ability of intraventricular 6-hydroxydopamine to lower rat brain I content. I had no effect on steady state levels or on the turnover of NA and dopamine in the rat brain. Apparently, I is a potent long acting selective inhibitor of 5-HT uptake in vivo.

The blockade of serotonin uptake into synaptosomes: relationship to an interaction with monoamine oxidase inhibitors: The blockade of serotonin uptake into synaptosomes: relationship to an interaction with monoamine oxidase inhibitors. Sinclair, John G.; Lo, Grace F. (Fac. Pharm. Sci., Univ. British Columbia, Vancouver, B. C., Can.). Can. J. Physiol. Pharmacol., 55(2), 180-7 (English) 1977. CODEN: CJPPA3. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Lilly 110140 (I) [56296-78-7] administered to phenelzine-pretreated rabbits produced a lethal hyperpyrexia in doses .gtoreq.2.5 mg/kg. The order of potency in blocking 14C-labeled serotonin (5-HT) [50-67-9] uptake into synaptosomes prepd. from rabbits was: I > meperidine-HCl [50-13-5] = dextromethorphan [125-71-3] = levorphanol tartrate [125-72-4] > anileridine [144-14-9] > alphaprodine [77-20-3] > morphine [57-27-2]. Since I, meperidine, and dextromethorphan produce hyperpyrexia in phenelzine-pretreated rabbits, whereas anileridine, alphaprodine, and morphine do not, there appears to be some correlation between the hyperpyrexic response and inhibition of 5-HT uptake. The exception is levorphanol, which is not hyperpyrexic despite being equipotent with meperidine and dextromethorphan in inhibiting 5-HT uptake. The ineffectiveness of levorphanol in producing hyperpyrexia may be due to its marked depressant properties, since the addn. of another depressant drug (pentobarbital) antagonized the hyperpyrexic effect of meperidine.

Detail of "56296-78-7"

Benzenepropanamine,N-methyl-g-[4-(trifluoromethyl)phenoxy]-,hydrochloride (1:1)

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CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

CAS No.56296-78-7 Fluoxetine hydrochloride

Reference