Reference

Compound for controlling weeds

Suchy, Milos (Hoffmann-La Roche, F., und Co. A.-G., Switz.). Braz. Pedido PI BR 7903159 25 Nov 1980, 36 pp. (Portuguese). (Brazil). CODEN: BPXXDX. CLASS: IC: C07C131-00; C07C079-22; C07C059-223; A01N037-163. APPLICATION: BR 79-3159 790521. DOCUMENT TYPE: Patent CA Section: 5 (Agrochemicals) The herbicides I (R1 = H, C1-6 alkyl, or phenyl; R2 H, C1-6 alkyl, C2-6 alkene, or Ph; R3 = H, F, Cl, Br, F3C, or NO2; R4 and R5 = H or Cl; R1 and R2 can be cyclized into a cyclohexane ring, which can be mono-, di-, or trisubstituted with C1-3 alkyls; R1 and R2 cannot be H simultaneously) are prepd. Thus, 5 g of acetone oxime [127-06-0] and 5.6 g of pyridine were dissolved in 80 mL THF before dropwise of 15 g 2-bromopropionic acid bromide [563-76-8]. The mixt. was left at room temp. (with stirring) for 3 h, chilled, and extd. with ether. The ether ext. was dried, and the 2-bromopropionylacetone oxime [72131-70-5] purified by absorption on silica gel. Fifteen mL tetrahydrofuren was added to 5 mL of a 50% suspension of NaH in petroleum before dropwise addn. of 5 g p-(p-chlorophenoxy)phenol [21567-18-0] in 30 mL DMF and of 5.2 g 2-bromopropionyl acetone oxime in 20 mL of DMF. The mixt. was refluxed for 2 h, chilled, extd. with either, and the product acetone O-[2-(p-chlorophenoxy)phenoxy)propionyl]oxime [72131-78-3] was purified by absorption on silica gel. Acetone O-2-[p-(p-bromophenoxy)phenoxy]propionyl oxime [72131-95-4] (625 g/ha) totally controlled Alopecurus myosuroides, and partially Digitaria floziodana.

Pyridazinones as cardiotonic drugs

Pyridazinones as cardiotonic drugs. (Mitsubishi Chemical Industries Co., Ltd., Japan). Jpn.Some commonly used reagents like 88555-37-7 and 88555-41-3 are used in this experiment. Kokai Tokkyo Koho JP 58183618 A2 26 Oct 1983 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K031-50. ICA: C07D237-04; C07D237-14. APPLICATION: JP 82-65950 20 Apr 1982. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 28 Pyridazinones I (R1 and R2 = H or C1-4 alkyl; R3 = C1-4 alkyl) or their salts are cardiotonic drugs. Thus, I (R1, R2, and R3 = Me) [39754-27-3] (300 mg) infused into isolated dog papillary muscle increased the constriction by 25%. This drug was prepd. by treating 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone [21282-90-6] with a-bromopropionyl bromide [563-76-8] to form 6-[4-(a-bromopropionylamino)phenyl]-4,5-dihydro-3(2H)-pyridazinon e [88555-37-7] which was in turn treated with dimethylamine [124-40-3]. .