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Detail of "5630-53-5"

  • CAS Number:
  • 5630-53-5
  • Name:

  • 19-Norpregn-5(10)-en-20-yn-3-one,17-hydroxy-7-methyl-, (7a,17a)-

  • Superlist Name:
  • Tibolone
  • Molecular Structure:
  • Formula:
  • C21H28O2
  • Molecular Weight:
  • 312.45
  • Deleted CAS:
  • 133677-19-7
  • Synonyms:
  • 19-Nor-17a-pregn-5(10)-en-20-yn-3-one, 17-hydroxy-7a-methyl- (7CI,8CI);(7a,17a)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one;7a-Methyl-17a-ethynyl-17b-hydroxy-5(10)-estren-3-one;7a-Methyl-D5,10-norethindrone;Livial;Liviella;Org OD 14;
  • EINECS:
  • 227-069-1
  • Density:
  • 1.13 g/cm3
  • Melting Point:
  • 169 °C
  • Boiling Point:
  • 447.4 °C at 760 mmHg
  • Flash Point:
  • 190.6 °C
  • Appearance:
  • white solid
  • Hazard Symbols:
  • DangerousN
  • Risk Codes:
  • 51/53
  • Safety:
  • 22-24/25-61 Details
  • Transport Information:
  • UN 3077 9/PG 3
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CAS No.5630-53-5 TiboloneCompetitive Product

Name:Tibolone Molecular Formula: C21H28O2 Molecular Weight: 312.45

Supplier:Shananxi Dongtaiyuan Chemical Technology Co.,Ltd. [ China (Mainland)]

Platinum
Supplier 975Integral
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Address:NO.263 Taibai South Road Beilin District Xi’an City Shaanxi Province China

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CAS No.5630-53-5 TiboloneCompetitive Product

Tibolone(EP)

Supplier:TCS INDUSTRY LIMITED [ China (Mainland)]

Platinum
Supplier 1590Integral
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CAS No.5630-53-5 Tibolone

Tibolone

Supplier:Anhui Charm Imp.&Exp.Co., Ltd [ China (Mainland)]

Platinum
Supplier 925Integral
925

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CAS No.5630-53-5 Tibolone

Supplier:Taizhou Crene Biotechnology co.ltd [ China (Mainland)]

Platinum
Supplier 1090Integral
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Address:Economic Developed Zone of Taizhou Zhejiang China

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CAS No.5630-53-5 Tibolone

  Package:46 kg/vacuum...Storage:store at RT  Transportation:by sea/air  Application:Tibolone

Supplier:SHAANXI TOP PHARM CHEMICAL CO.LTD [ China (Mainland)]

Platinum
Supplier 370Integral
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CAS No.5630-53-5 Tibolone

Assay:98%min.  Appearance:white crysta...  Package:as per custo...

Supplier:Shanghai Longschem Co.,Ltd [ China (Mainland)]

Platinum
Supplier 960Integral
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CAS No.5630-53-5 Tibolone

Tibolone CAS RN 5630-53-5 EINECS 227-069-1 MF C21H28O2 MW 312.45 99% WHITE OR OFF-WHITE CRYSTALLINE POWDER

Supplier:Jinan Wedo Industrial Co., Ltd. [ China (Mainland)]

Platinum
Supplier 1590Integral
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CAS No.5630-53-5 Tibolone

Assay:99%  Appearance:White crysta...

Supplier:Taiyuan RHF CO., ltd. [ China (Mainland)]

Platinum
Supplier 2160Integral
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Address:Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi

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CAS No.5630-53-5 Tibolone

Tibolone

Supplier:ZHEJIANG HOLYPHARM BIOTECH CO.,LTD [ China (Mainland)]

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Supplier 1585Integral
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CAS No.5630-53-5 Tibolone

TIBOLONE---We supply this product in very competitive price.

Supplier:Hangzhou UNIWISE International Co.,Ltd. [ China (Mainland)]

Platinum
Supplier 1525Integral
1525

Tel:+86-571-28819531

Address:E-19F, Dongqiing Building, 52 Qingchun Rd, Hangzhou, China

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CAS No.5630-53-5 Tibolone

Supplier:LIDE PHARMACEUTICALS LIMITED [ China (Mainland)]

Platinum
Supplier 965Integral
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Address:11F, Building A1, No.288 North Zhongshan Road, Gulou District, Nanjing,210003, P.R.China.

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CAS No.5630-53-5 Tibolone

Supplier:Jinan Haohua Industry CO., LTD [ China (Mainland)]

Platinum
Supplier 920Integral
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CAS No.5630-53-5 Tibolone

Supplier:ChemOrganic Limited [ China (Mainland)]

Platinum
Supplier 1375Integral
1375

Tel:0571-28183299

Address:Room 608,Building B , Zhejiang University science park, #525 Xixi Road ,hangzhou,China.

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CAS No.5630-53-5 Tibolone

Supplier:Luyu Import & Export Group Company Limited [ China (Mainland)]

Gold
Supplier 325Integral
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Address:518 Room,1# Building ,88# Cailun Road

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CAS No.5630-53-5 Tibolone

  Package:foil bag  Transportation:EMS,DHL,by A...

Product name: Tibolone Synonym: TIBOLONE;LIVIELLA;LIVIAL;5(10)-ESTREN-7-ALPHA-METHYL-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE;(7A,17A)-17-HYDROXY-7-METHYL-19-NORPREGN-5(10)-EN-20-YL-3-ONE;17-hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one;17ALPHA-HYDROXY-7ALPHA-METHYL-19-NORPREG

Min. Order:1Kilogram

Supplier:Wuhan Yuancheng Gongchuang Technology Co.,Ltd. [ China (Mainland)]

Silver
Supplier KOSHER 1814Integral
1814

Tel:+86-27-88083115

Address:496, Zhongshan Road, Wuchang, Wuhan, China

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CAS No.5630-53-5 Tibolone

Assay:98%  Appearance:yellow cryst...  Package:100g/foil ba...

Name: Trenbolone Acetate yellow powder Trenbolone Acetate Content: 99% powder MF: C20H24O3 MW: 312.41 CAS: 10161-34-9 EINECS: 233-432-5 Quality standard: Enterprise Standard Apperance: yellow crystalline powder Packing: as your require Storage: shading, confined pres

Min. Order:100Gram

Supplier:JIA-SHING Business Trade Macau Co., Ltd. [ Macao]

420Integral
420

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Address:23rd Floor, Block 3 La Cite, Areia Preta, Macao

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CAS No.5630-53-5 Tibolone

Name: Tibolone CAS NO: 5630-53-5 Content: 99% Molecular Formula: C21H28O2　 Quality standard: USP31/CP2005 Apperance: white or off-white crystalline powder Packing: 25kg/barrel Storage: shading, confined preservation.

Supplier:KA-SHING Business Trade Macau Co., Ltd. [ Macao]

500Integral
500

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CAS No.5630-53-5 Tibolone

Supplier:Exim-Pharm International [ India]

10Integral
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Address:1, Ashish Mahal, 2nd Floor, Ist Road, Golibar Santacruz (E) Mumbai - 400 055, Maharashtra, (India)

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CAS No.5630-53-5 Tibolone

Supplier:Lanza Pharma Ltda. [ Brazil]

600Integral
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CAS No.5630-53-5 Tibolone

Supplier:Euticals [ Italy]

600Integral
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Address:Origgio

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Reference

Multicenter study of effects of Org OD 14 on endometrium, vaginal cytology and cervical mucus in post-menopausal and oophorectomized women
Multicenter study of effects of Org OD 14 on endometrium, vaginal cytology and cervical mucus in post-menopausal and oophorectomized women. Punnonen, R.; Liukko, P.; Cortex-Prieto, J.; Eydam, F.; Milojevic, S.; Trevoux, R.; Chryssikopoulos, E.; Franchi, F.; Luisi, M.; Kicovic, P. M. (Dep. Gynaecol. Obstetr., Univ. Turku, Turku, Finland). Maturitas, 5(4), 281-6 (English) 1984. CODEN: MATUDK. ISSN: 0378-5122. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) A study of 69 post-menopausal or oophorectomized women was performed to det. whether Org OD 14 [(7a,17a)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one](I) [5630-53-5] administered orally in a daily dose of 2.5 mg for 90 days induces endometrial proliferation. The treatment with Org OD 14 wascontinued in combination with a 1 mg daily dose of lynestrenol [52-76-6] from day 91 for 10 days to ascertain whether secretory transformation of the endometrium and subsequent withdrawal bleeding would occur. Endometrial biopsies were obtained before treatment and on day 91. The effects of Org OD 14 on vaginal mucosa and cervical mucus were also evaluated. Org OD 14 did not display any effect on the endometrium in 56 of the study subjects. Weak stimulation (initial proliferation was seen in 11 of the subjects, and withdrawal bleeding occurred in only 5 of these after cessation of the combined treatment with lynestrenol. However, moderate estrogenic effects on vaginal mucosa and cervical mucus were induced in all study subjects.
A primate model of human postmenopausal hot flushes
A primate model of human postmenopausal hot flushes. Jelinek, J.; Kappen, A.; Schoenbaum, E.; Lomax, P. (Organon Sci. Dev. Group, Oss, Neth.). J. Clin. Endocrinol. Metab., 59(6), 1224-8 (English) 1984. CODEN: JCEMAZ. ISSN: 0021-972X. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 13 An animal model was developed for the study of hot flushes. Female monkeys (Macaca arctoides) were trained to accept monitoring of scalp cutaneous temps. After baseline temp. recordings were obtained both monkeys were ovariectomized. A few days after operation the previously stable scalp temp. changed to an undulating pattern with cycles lasting approx. 40-50 min. Ethynylestradiol [57-63-6] (20 mg orally or i.m.) and (7a,17a)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one [5630-53-5] (2.5 mg orally), a steroid with weak estrogenic, progestogenic, and androgenic properties, suppressed the characteristic undulating temp. pattern; this returned after withdrawal of replacement therapy. Clonidine [4205-90-7] (0.15 mg twice a day) suppressed the cyclic changes for 2 to 3 h. Domperidone and naloxone had no effect. This animal model may be useful for the investigation of alternative therapy for the management of menopausal flushes.
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