Reference

Zinc methionine complex for acne treatment

Zinc methionine complex for acne treatment. Abdel-Monem, Mahmoud M. (Zinpro Corp., USA). U.S. US 4039681 2 Aug 1977, 6 pp. Cont.-in-part of U.S. 3,941,818. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-315. NCL: 424289000. APPLICATION: US 73-390080 20 Aug 1973. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Zn-methionine complex inorg. salts (I:X = nontoxic inorg. anion which does not inhibit the therapeutic effectiveness of the Zn complex; Y = integer equal to the anionic charge of X) are used in compns. for the treatment of acne. For example, a soln. of 28.75 g hydrated ZnSO4 and 14.9 g methionine in 100 mL H2O was treated with 3000 mL Me2CO to give 31.0 g zinc methionine sulfate (II) [56329-42-1]. Administration of 2-14C-labeled II to rats showed that the complex provided a greater body conversion of methionine to protein than was obtained by administration of methionine alone. Administration of II (100 mg twice daily, orally) to acne vulgaris patients along with daily facial cleansing significantly aided in decreasing the severity of the acne in only 6 weeks.