CAS No.56341-41-4,5-Fluoro-2-oxindole Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	56341-41-4
Name:	5-Fluoro-2-oxindole
Article Data:	75

Formula:	C₈H₆FNO
Molecular Weight:	151.14
Synonyms:	5-Fluoro-1,3-dihydro-2H-indol-2-one;5-Fluoro-1,3-dihydroindol-2-one;5-Fluoro-2,3-dihydro-2-oxoindole;5-Fluoro-2-oxoindoline;5-Fluoroindolin-2-one;5-Fluoro-1,3-dihydro-indol-2-one;
EINECS:	446-540-4
Density:	1.311 g/cm³
Melting Point:	143-147 °C(lit.)
Boiling Point:	307.197 °C at 760 mmHg
Flash Point:	139.588 °C
Appearance:	Light Yellow Crystalline
Hazard Symbols:	Xi, C
Risk Codes:	36/37/38-34
Safety:	22-24/25-45-36/37/322-24/25-45-36/37/39-27-269-27-26
PSA:	29.10000
LogP:	1.45830

Synthetic route

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With hydrazine hydrate In water at 140℃; for 6h; Temperature; Wolff-Kishner-Huang Minlon Reduction;	99.1%
With titanium tetrachloride; zinc In tetrahydrofuran at 20℃; for 0.1h; Inert atmosphere;	87%
Stage #1: 5-fluoro-1H-indole-2,3-dione With potassium hydroxide; hydrazine In ethylene glycol at 80℃; for 3h; Stage #2: With hydrogenchloride; water In ethylene glycol at 0 - 20℃; for 12h; pH=1 - 2;	81.9%

: 389571-36-2
5-fluoro-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water for 2h; Reagent/catalyst; Temperature; Inert atmosphere; Reflux;	92.1%
Stage #1: 5-fluoro-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester With hydrogenchloride In methanol; water at 80℃; for 5h; Stage #2: With potassium hydroxide In methanol; water at 40℃; for 0.5h;

: 79-04-9
chloroacetyl chloride

: 371-40-4
4-fluoroaniline

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With montmorillonite KSF at 20℃; for 1.08333h; Stolle synthesis; Sonication; Neat (no solvent);	88%

: 29640-99-1
methyl 2-(5-fluoro-2-nitrophenyl)acetate

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With iron In acetic acid at 100℃; for 1h;	87%

: 18108-55-9
1,3-dihydro-1-hydroxyindole-2-one

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With diethylamino-sulfur trifluoride In dichloromethane at 0℃; for 0.0833333h;	81%

: 283584-52-1
5-fluoro-3-hydrazonoindolin-2-one

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 5h; Reflux;	80.4%
With potassium tert-butylate In ethanol for 2h; Reflux; Inert atmosphere;
With sodium ethanolate

: 351-83-7
4'-fluoroacetanilide

: 623-48-3
ethyl iodoacetae

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With silver(I) acetate; palladium diacetate; trifluoroacetic acid at 120℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique;	78%

: 29640-98-0
(5-Fluoro-2-nitro-phenyl)-acetic Acid

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With ammonium formate on silica gel; zinc In carbon dioxide at 50℃; under 90009 Torr; Autoclave; liquid CO2;	76%

: (E)-5-fluoro-3-hydrazonoindolin-2-one

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 6h; Reflux;	73.6%

: 356068-89-8
(2-amino-5-fluoro-phenyl)-acetic acid hydrazide

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
In water	73%
In water	73%
With hydrogenchloride In water at 20℃; for 12h; pH=3;	73%

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Chemistry

IUPAC Name: 5-Fluoro-1,3-dihydroindol-2-one
Molecular Formula: C₈H₆FNO
Molecular Weight: 151.14 g/mol
Canonical SMILES: C1C2=C(C=CC(=C2)F)NC1=O
InChI: InChI=1S/C8H6FNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
Product Categories: INDOLE; blocks; FluoroCompounds; IndolesOxindoles; Indole/indoline/oxindole; Indole and Indoline; Heterocycles; Indoles and derivatives; Halides; Pyrroles & Indoles; ketone; Sunitinib; Aromatics Compounds; Intermediate of sunitinib malate; Aromatics; Pyrroles & Indoles; Boronic Acid;Heterocyclic Compounds; Building Blocks; Heterocyclic Building Blocks; Indoles; Fluorinated heterocyclic series
Index of Refraction: 1.56
Molar Refractivity: 37.28 cm³
Molar Volume: 115.2 cm³
Polarizability: 14.78×10^-24 cm³
Surface Tension: 41.8 dyne/cm
Density: 1.311 g/cm³
Flash Point: 139.6 °C
Enthalpy of Vaporization: 54.78 kJ/mol
Boiling Point: 307.2 °C at 760 mmHg
Melting Point: 143-147 °C(lit.)
Storage temperature: Keep Cold
Vapour Pressure of 5-Fluorooxindole (CAS NO.56341-41-4): 0.000736 mmHg at 25 °C

Safety Profile

Safty informations of 5-Fluorooxindole (CAS NO.56341-41-4):
Hazard Codes: Irritant Xi Corrosive C
Risk Statements: 36/37/38-34
R36/37/38:Irritating to eyes, respiratory system and skin.
R34:Causes burns.
Safety Statements: 22-24/25-45-36/37/39-27-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S27:Take off immediately all contaminated clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT, KEEP COLD

Specification

5-Fluorooxindole (CAS NO.56341-41-4), its Synonyms are 5-Fluoroindole-2-One ; 5-Fluoro-1,3-dihydro-indol-2-one ; 5-Fluorooxindole 98% . It is light yellow crystalline.