Detail of "56552-80-8"

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Interaction of hopanoids with phosphatidylcholines containing oleic and w-cyclohexyldodecanoic acid in lipid bilayer membranes

Interaction of hopanoids with phosphatidylcholines containing oleic and w-cyclohexyldodecanoic acid in lipid bilayer membranes. Benz, Roland; Hallmann, Dieter; Poralla, Karl; Eibl, Hansjoerg (Fak. Biol., Univ. Konstanz, Konstanz D-7750, Fed. Rep. Ger.). Chem. Phys. Lipids, 34(1), 7-24 (English) 1983. CODEN: CPLIA4. ISSN: 0009-3084. DOCUMENT TYPE: Journal CA Section: 6 (General Biochemistry) Lipid bilayer membranes were made from hopanoid phosphatidylcholine mixts. dissolved in decane. The specific capacity of the mixed membranes increased with increasing hopanoid content. This indicates an interaction between hopanoids and lipids which leads to a redn. of the chem. potential of the solvent in the membranes. The structural properties of mixts. of hopanoids and phosphatidylcholines were investigated with charged probe mols., the neg. charged lipophilic ions dipicrylamine (DPA) and tetraphenylborate, and the pos. charged K complex PV-K+ [PV, cyclo(D-Val-L-Pro-L-Val-D-Pro)3]. The transport properties of lipophilic ions in the mixed membranes indicate that the elec. properties, like dipolar potential and surface potentials, of phosphatidylcholine membranes are not changed by insertion of hopanoids. 18017-77-1 and 56552-80-8 which are cas registry numbers of chemicals are mentioned. The translocation rate const., K, of the PV-K+ complex is drastically reduced in hopanoid-phosphatidylcholine membranes with increasing hopanoid content. This effect is discussed on the basis of an alteration of the microviscosity in the mixed membranes. There is a close analogy between the action of cholesterol and hopanoids in phosphatidylcholine bilayer membranes. A bilayer membrane of di-w-cyclohexyldodecanoylphosphatidylcholine had a higher specific capacity as compared to other phosphatidylcholines. Also, a lower translocation rate const. for PV-K+ was obsd.; this may be caused by the relative high microviscosity of this lipid, even above the phase transition temp. .