Reference

Cyanoalkylureidocephalosporins

Cyanoalkylureidocephalosporins.Some chemicals with cas registry numbers like 56610-72-1 are also used. Breuer, Hermann; Treuner, Uwe D.In this experiment, several chemicals are used like 56610-72-1 (Chemische Fabrik von Heyden G.m.b.H., Ger.). Ger. Offen. DE 2707490 8 Sep 1977, 73 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07D501-20. PRIORITY: US 76-664128 5 Mar 1976. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) The cephalosporins I (R = H, Me, Et, etc.; R1 = thienyl, furyl, Ph, etc.; R2 = H, MeO; R3 = H, Na, CHPh2, CMe3, etc.; R4 = AcO, pyridinio, 1-methyl-1H-tetrazol-5-ylthio, etc.; Z = CH2, CH2CH2, CHMe, etc.) were prepd. for use as antibiotics (no data). Thus, D-4-MeOC6H4CH2O2CNHCHR1CO2H (R1 = 2-thienyl) reacted with II (R5 = H) and dicyclohexylcarbodiimide in CH2Cl2-THF to give II (R5 = D-4-MeOC6H4CH2O2CNHCHR1CO), which was treated with F3CCO2H in anisole to give II (R5 = H2NCHR1CO) (III). Addn. of NCCH2NCO to a suspension of II in CH2Cl2-Et3N, followed by treatment with Na2CO3 gave D-I (R = R2 = H, R1 = 2-thienyl, R3 = Na, R4 = 1-methyl-1H-tetrazol-5-ylthio, Z = CH2). ..

Cyanoalkylureidocephalosporins

Cyanoalkylureidocephalosporins.Some chemicals with cas registry numbers like 56610-72-1 are also used. Breuer, Hermann; Treuner, Uwe D.In this experiment, several chemicals are used like 56610-72-1 (Chemische Fabrik von Heyden G.m.b.H., Ger.). Ger. Offen. DE 2707490 8 Sep 1977, 73 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07D501-20. PRIORITY: US 76-664128 5 Mar 1976. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) The cephalosporins I (R = H, Me, Et, etc.; R1 = thienyl, furyl, Ph, etc.; R2 = H, MeO; R3 = H, Na, CHPh2, CMe3, etc.; R4 = AcO, pyridinio, 1-methyl-1H-tetrazol-5-ylthio, etc.; Z = CH2, CH2CH2, CHMe, etc.) were prepd. for use as antibiotics (no data). Thus, D-4-MeOC6H4CH2O2CNHCHR1CO2H (R1 = 2-thienyl) reacted with II (R5 = H) and dicyclohexylcarbodiimide in CH2Cl2-THF to give II (R5 = D-4-MeOC6H4CH2O2CNHCHR1CO), which was treated with F3CCO2H in anisole to give II (R5 = H2NCHR1CO) (III). Addn. of NCCH2NCO to a suspension of II in CH2Cl2-Et3N, followed by treatment with Na2CO3 gave D-I (R = R2 = H, R1 = 2-thienyl, R3 = Na, R4 = 1-methyl-1H-tetrazol-5-ylthio, Z = CH2). ..