Detail of "56777-24-3"

CAS Number:
56777-24-3
Name:
Propanoic acid,2-hydroxy-, phenylmethyl ester, (2S)-
Molecular Structure:
Formula:
C10H12 O3
Molecular Weight:
180.2
Synonyms:
Propanoicacid, 2-hydroxy-, phenylmethyl ester, (S)-; (2S)-2-Hydroxypropionic acid benzylester; (S)-Benzyl 2-hydroxypropanoate; Benzyl (S)-(-)-lactate; Benzyl(S)-2-hydroxypropionate; Benzyl (S)-lactate; Benzyl L-lactate; L-Lactic acidbenzyl ester
Melting Point:
17 °C
Boiling Point:
105-109 °C0.1 mm Hg(lit.)

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: Some chemicals with cas registry numbers like 56777-24-3 are also used. 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: Synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV. Lynch, Christopher L.; Hale, Jeffrey J.; Budhu, Richard J.; Gentry, Amy L.; Mills, Sander G.; Chapman, Kevin T.; MacCoss, Malcolm; Malkowitz, Lorraine; Springer, Martin S.; Gould, Sandra L.; DeMartino, Julie A.; Siciliano, Salvatore J.; Cascieri, Margaret A.; Carella, Anthony; Carver, Gwen; Holmes, Karen; Schleif, William A.; Danzeisen, Renee; Hazuda, Daria; Kessler, Joseph; Lineberger, Janet; Miller, Michael; Emini, Emilio A. (Merck Research Laboratories, Department of Medicinal Chemistry, Rahway, NJ 07065, USA). Bioorganic & Medicinal Chemistry Letters, 12(20), 3001-3004 (English) 2002 Elsevier Science Ltd. CODEN: BMCLE8. ISSN: 0960-894X. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 A series of a-(pyrrolidin-1-yl)acetic acids I [R1 = H, Me, Me2CH, cyclopropyl, cyclobutylmethyl, cyclohexyl, Ph, etc.; R2 = Ph(CH2)3, 4-FC6H4; R3 = H, HO] was prepd. and investigated as selective and potent antivirals against HIV. Several of the pyrrolidine zwitterions demonstrated reasonable in vitro properties, enhanced antiviral activities and improved pharmacokinetic profiles over the lead pyrrolidine. .