Reference

Effects of cephem antibiotics on ethanol metabolism

Effects of cephem antibiotics on ethanol metabolism. Nakamura, Kanichi; Nakagawa, Akihiko; Tanaka, Minoru; Masuda, Hiroshi; Hayashi, Yasuyuki; Saionji, Katsu (Anal. Metab. Res. Lab., Sankyo Co., Ltd., Tokyo 140, Japan). Nippon Yakurigaku Zasshi, 83(2), 183-91 (Japanese) 1984. CODEN: NYKZAU. ISSN: 0015-5691. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 1 The mechanism of EtOH [64-17-5] deterrent effects of cefmetazole (CMZ)(I) [56796-20-4], latamoxef (LMOX) [64952-97-2], and cefoperazone (CPZ) [62893-19-0] was detd. in humans, monkeys, dogs and rats. The 24-h urinary content of mercaptomethyltetrazole (II) [13183-79-4] (a metabolite of these antibiotics) in humans after a single i.v. administration of various antibiotics (1 g/subject) was in the order: CPZ > LMOX > CMZ. The contents were 39, 14, and 3%, resp., of the administered dose. Similar phenomena were obsd. in rats and monkeys. In sep.Several substances with their cas registry numbers 62893-19-0 and 13183-79-4 may be metioned in this study. expts., oral administration of EtOH after a single i.v. dose of CMZ, LMOX and CPZ to rats resulted in a dose-dependent increase in blood AcH [75-07-0] levels accompanied by an increase in urinary contents of II. The effect was most pronounced for CPZ, followed by LMOX and CMZ. Similar results were noted in monkeys given EtOH after i.v. administration of 2 doses of CMZ and esp. CPZ. Thus, II appears to play an important role in the alc. deterrent effect of these antibodies. Species differences in the sensitivity to the alc. deterrent effect of those compds. were indicated. .

Suppository bases for b-lactam antibiotics

Suppository bases for b-lactam antibiotics.Some chemicals with cas registry numbers like 9002-92-0 and 90013-55-1 are also used. (Sankyo Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 59021612 A2 3 Feb 1984 Showa, 8 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K009-02. ICA: A61K031-545. APPLICATION: JP 82-131653 28 Jul 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 Suppository bases for b-lactam antibiotics, contain plant oils, and nonionic surfactants. The absorption of the antibiotics was enhanced by these bases. Thus, 3 parts polyethylene glycol lauryl ether [9002-92-0] was added to 97 parts olive oil at a high temp. to form a base. Then, 2 g I [56796-20-4] was dispersed in 18 g of the base and made into 2 g suppositoriesd. The rate of rectal absorption was demonstrated in dogs. .