Reference

Stability of phenylbutazone in presence of pharmaceutical colors

Stability of phenylbutazone in presence of pharmaceutical colors. Baugh, Rosalind; Calvert, R. T.; Fell, J. T. (Pharm. Dep., Univ. Manchester, Manchester, Engl.). J. Pharm. Sci., 66(5), 733-5 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The degrdn. of phenylbutazone (I) [50-33-9] was studied in the presence of lakes suitable for coloring the sugar coats of I tablets. I was degraded, in light in the presence of FD and C Red lake No. 3 (erythrosine Na lake) [53026-61-2] at a rate increasing with lake concn., and was also degraded more slowly in a soln. of 0.0078% (wt./vol.) erythrosine Na [568-63-8]. The degrdn. probably proceeds via O generated by the light-excited dye. The degrdn. may be important in some quality control procedures and can lead, for example, to unusual results in dissoln. rate testing.

Detection of deposits on surfaces of contact lenses

Detection of deposits on surfaces of contact lenses. (Tokyo Contact Lens Research Institute, Japan). Jpn. Kokai Tokkyo Koho JP 58222155 A2 23 Dec 1983 Showa, 3 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C09B057-14; G02C007-04; G02C013-00. APPLICATION: JP 82-103744 18 Jun 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Albumins and lysozyme monochloride [52219-07-5] excreted from tears and adhering to contact lens are detected with a dye, I [568-63-8]. 52219-07-5 and 16423-68-0 are also in the experiment. Thus, in a test system, albumins and lysozyme placed on a contact lens showed a red color when exposed to 0.5% I aq. soln. (pH 4-7). .