CAS No.5697-56-3,Olean-12-en-29-oicacid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, (3b,20b)- Suppliers

Detail of "5697-56-3"

CAS Number:

5697-56-3

Name:

Olean-12-en-29-oicacid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, (3b,20b)-

Superlist Name:

Carbenoxolone

Molecular Structure:

Formula:

C₃₄H₅₀O₇

Molecular Weight:

570.76

Deleted CAS:

108064-10-4,13020-80-9,60093-85-8,885512-34-5,906421-35-0

Synonyms:

Olean-12-en-30-oicacid, 3b-hydroxy-11-oxo-, hydrogensuccinate (7CI,8CI);Olean-12-en-30-oic acid, 3b-hydroxy-11-oxo-, succinate (6CI);3-O-(b-Carboxypropionyl)-11-oxo-18b-olean-12-en-30-oic acid;3b-Hydroxy-11-oxoolean-12-en-30-oicacid hydrogen succinate;Biogastrone;Glycyrrhetinic acidhydrogen succinate;

EINECS:

227-174-2

Density:

1.2 g/cm³

Melting Point:

291-294 °C

Boiling Point:

687.4 °C at 760 mmHg

Flash Point:

211.6 °C

Reference

Effects of carbenoxolone on prostaglandin synthesis and degradation: Effects of carbenoxolone on prostaglandin synthesis and degradation. Peskar, B. M. (Med. Univ.-Klin., Freiburg/Br., Ger.). Verh. Dtsch. Ges. Inn. Med., 82(1), 1009-10 (German) 1976. CODEN: VDGIA2. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Carbenoxolone (I) [5697-56-3] inhibited the prostaglandin-degrading enzymes in human gastric mucosa and guinea pig lung in vitro, but had relatively little effect on the enzymes of prostaglandin synthesis in human gastric mucosa and guinea pig kidney. I treatment may therefore increase the levels of endogenous prostaglandins in the gastric mucosa and thus promote ulcer healing.

On the synthesis of prostaglandins by human gastric mucosa and its modification by drugs: On the synthesis of prostaglandins by human gastric mucosa and its modification by drugs. Peskar, B. M. (Med. Klin., Univ. Freiburg, Freiburg/Br., Ger.). Biochim. Biophys. Acta, 487(2), 307-14 (English) 1977. CODEN: BBACAQ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 13 Prostaglandin E2 [363-24-6] and prostaglandin F2.alpha. [551-11-1] were formed from arachidonic acid [506-32-1] by the microsomal fraction of human gastric mucosa. Synthesis of prostaglandin A2 [13345-50-1] or prostaglandin B2 [13367-85-6] was not obsd. under the same incubation conditions. Indometacin (I) [53-86-1] effectively inhibited synthesis of both prostaglandin E2 (ID50 4.2 .mu.g/mL) and prostaglandin F2.alpha. (ID50 1.8 .mu.g/mL) by human gastric mucosa, paracetamol (II) [103-90-2] even at concns. of 310 .mu.g/mL did not influence prostaglandin synthesis. The anti-ulcer agent carbenoxolone (III) [5697-56-3], which inhibits prostaglandin inactivation, only slightly inhibited prostaglandin synthesis at 310 .mu.g/mL. The results support the hypothesis that the gastro-intestinal effects or side effects of several drugs are mediated by an influence on the enzymes of prostaglandin synthesis or inactivation.

Detail of "5697-56-3"

Olean-12-en-29-oicacid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, (3b,20b)-

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Reference