CAS No.57-14-7,1,1-Dimethylhydrazine Suppliers,MSDS download

CAS No.:	57-14-7
Name:	1,1-Dimethylhydrazine
Article Data:	64
Molecular Structure:

Formula:	C₂H₈N₂
Molecular Weight:	60.0989
Synonyms:	1,1-Dimethylhydrazine;Dimazin;Dimazine;Heptyl;N,N-Dimethylhydrazine;NSC 60517;UDMH;Unsymmetrical dimethylhydrazine;as-Dimethylhydrazine;gem-Dimethylhydrazine;u-Dimethylhydrazine;unsym-Dimethylhydrazine;
EINECS:	200-316-0
Density:	0.829 g/cm³
Melting Point:	-57.2 °C
Boiling Point:	63.9 °C at 760 mmHg
Flash Point:	1.1 °C
Solubility:	miscible with water, ethanol, and kerosene
Appearance:	clear colorless liquid with an ammonia-like odor
Hazard Symbols:	F, T, N
Risk Codes:	45-11-23/25-34-51/53
Safety:	53-45-61
Transport Information:	UN 1163
PSA:	29.26000
LogP:	0.12200

Conditions	Yield
With hydrogenchloride In ethanol	A 92% B n/a

Conditions	Yield
With (η5-C5Me5)Rh(2-pyridylphenyl)H; hydrogen In tetrahydrofuran at 23℃; under 3040.2 Torr; for 120h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Schlenk technique;	87%

Conditions	Yield
With hydrogenchloride; formaldehyd; paraformaldehyde; platinum	78%

Conditions	Yield
With titanium(III) chloride In water for 1h; Ambient temperature;	70%
With lithium aluminium tetrahydride; diethyl ether
With sodium hydroxide; aluminium

Conditions	Yield
With cyclopentadienylchromiumtricarbonyl hydride; hydrogen In tetrahydrofuran at 23℃; under 3040.2 Torr; for 120h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Schlenk technique;	15%

Conditions	Yield
With ammonia
With ammonia; dimethyl amine at 35℃; under 9000.72 Torr; for 0.833333h; Product distribution; Further Variations:; educt/reagent ratios;
With sodium amide In kerosene
With tri-n-propylamine
With ammonium hydroxide at 25℃; pH=13; Kinetics;

Conditions	Yield
With acetic acid; zinc
With sulfuric acid durch elektrolytische Reduktion an einer verzinnten Kupferkathode;

Conditions	Yield
With xylene und Erhitzen des in Xylol unloeslichen Anteils des Reaktionsprodukts mit konz. Salzsaeure im Autoklaven auf 150grad;

Conditions	Yield
at 170 - 250℃;

Specification

The IUPAC name of this chemical is 1,1-dimethylhydrazine. With the CAS registry number 57-14-7 and EINECS 200-316-0, it is also named as Dimethylhydrazine unsymmetrical. The classification codes are Mutation data; Reproductive Effect; Tumor data. It is clear colorless liquid with an ammonia-like odor which is miscible with water, ethanol, and kerosene. It turns yellowish on exposure to air and absorbs oxygen and carbon dioxide. Moreover, this chemical is a powerful reducing agent and can exhibit high acute toxicity as a result of exposure by all routes. When heated to decomposition it emits highly toxic fumes of NO_x. In addition, 1,1-Dimethylhydrazine should be sealed in the container and stored in the cool and dry place which must be away from oxidant and acids.

The other characteristics of this product can be summarized as: (1)ACD/LogP: -1.28; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.85; (4)ACD/LogD (pH 7.4): -2.16; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 6.48 Å²; (13)Index of Refraction: 1.426; (14)Molar Refractivity: 18.57 cm³; (15)Molar Volume: 72.4 cm³; (16)Polarizability: 7.36×10^-24 cm³; (17)Surface Tension: 27.8 dyne/cm; (18)Density: 0.829 g/cm³; (19)Flash Point: 1.1 °C; (20)Enthalpy of Vaporization: 30.6 kJ/mol; (21)Boiling Point: 63.9 °C at 760 mmHg; (22)Vapour Pressure: 168 mmHg at 25°C.

Preparation of 1,1-Dimethylhydrazine: It can be obtained by the reaction of ammonia, ammonium chloride and dimethylamine. First, we can get chloro amine by ammonia and sodium hypochlorite. Secondly, the reaction of chloro amine and dimethylamine aqueous solution can generate UDMH solution. Finally, after a series of treatment, we can get the product.
NH₃+NaOCl→NH₂Cl+NaOH
NH₂Cl+HN(CH₃)₃+NaOH→(CH₃)₂NNH₂+NaCl+H₂O

Uses of 1,1-Dimethylhydrazine: It is often used in hypergolic rocket fuels as a bipropellant in combination with the oxidizer nitrogen tetroxide and less frequently with IRFNA (red fuming nitric acid) or liquid oxygen. It is also used in the production of plant growth regulator. What's more, this chemical is used as fuel additive and used in organic synthesis. In addition, it can react with pyridine-3-carbaldehyde to get pyridine-3-carbaldehyde-dimethylhydrazone. This reaction needs solvent ethanol by heating on a steam bath. The reaction time is 30 min. The yield is 77%.

1,1-Dimethylhydrazine can react with pyridine-3-carbaldehyde to get pyridine-3-carbaldehyde-dimethylhydrazone

When you are using this chemical, please be cautious about it as the following:
It is highly flammable and can cause burns and cancer. What's more, it is toxic by inhalation and if swallowed. And it is also toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) So it should avoid exposure - obtain special instructions before use and avoid release to the environment. Refer to special instructions / safety data sheets.

People can use the following data to convert to the molecule structure.
1. SMILES:N(N)(C)C
2. InChI:InChI=1/C2H8N2/c1-4(2)3/h3H2,1-2H3
3. InChIKey:RHUYHJGZWVXEHW-UHFFFAOYAL

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intraperitoneal	30mg/kg (30mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION LUNGS, THORAX, OR RESPIRATION: CYANOSIS	European Journal of Toxicology and Environmental Hygiene. Vol. 7, Pg. 238, 1974.
dog	LC50	inhalation	3580ppm/15M (3580ppm)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	American Industrial Hygiene Association Journal. Vol. 24, Pg. 137, 1963.
dog	LD50	intraperitoneal	60mg/kg (60mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING	National Technical Information Service. Vol. AD292-689,
dog	LD50	intravenous	60mg/kg (60mg/kg)		Medycyna Pracy. Industrial Medicine. Vol. 24, Pg. 71, 1973.
dog	LDLo	skin	301mg/kg (301mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology and Applied Pharmacology. Vol. 18, Pg. 649, 1971.
guinea pig	LC50	inhalation	100mg/m³/4H (100mg/m³)		Toksikologicheskii Vestnik. Vol. (6), Pg. 39, 1999.
guinea pig	LD50	skin	1329mg/kg (1329mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	U.S. Army Chemical Warfare Laboratories. Vol. CWL,
hamster	LC50	inhalation	392ppm/4H (392ppm)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	AMA Archives of Industrial Health. Vol. 12, Pg. 609, 1955.
hamster	LD50	subcutaneous	325mg/kg (325mg/kg)		Cancer Letters Vol. 35, Pg. 303, 1987.
human	TDLo	unreported	10mg/kg (10mg/kg)	BEHAVIORAL: HEADACHE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: LIVER FUNCTION TESTS IMPAIRED	"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 71, 1999.
monkey	LD50	intraperitoneal	60mg/kg (60mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING	National Technical Information Service. Vol. AD292-689,
mouse	LC50	inhalation	172ppm/4H (172ppm)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	AMA Archives of Industrial Health. Vol. 12, Pg. 609, 1955.
mouse	LD50	intraperitoneal	113mg/kg (113mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Proceedings of the Society for Experimental Biology and Medicine. Vol. 124, Pg. 172, 1967.
mouse	LD50	intravenous	250mg/kg (250mg/kg)		Medycyna Pracy. Industrial Medicine. Vol. 24, Pg. 71, 1973.
mouse	LD50	oral	155mg/kg (155mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 71, 1999.
rabbit	LD50	skin	1060mg/kg (1060mg/kg)		"Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 5, Pg. 210.1(89), 1986.
rat	LC50	inhalation	252ppm/4H (252ppm)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	AMA Archives of Industrial Health. Vol. 12, Pg. 609, 1955.
rat	LD50	intraperitoneal	102mg/kg (102mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology and Applied Pharmacology. Vol. 6, Pg. 371, 1964.
rat	LD50	intravenous	119mg/kg (119mg/kg)		Medycyna Pracy. Industrial Medicine. Vol. 24, Pg. 71, 1973.
rat	LD50	oral	122mg/kg (122mg/kg)		Medycyna Pracy. Industrial Medicine. Vol. 24, Pg. 71, 1973.
rat	LD50	skin	770mg/kg (770mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 71, 1999.
rat	LDLo	intracrebral	27mg/kg (27mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Biochemical Pharmacology. Vol. 14, Pg. 1901, 1965.

57-14-7

57-14-7

Consensus Reports

Standards and Recommendations

Specification