Detail of "57-33-0"

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CAS Number:
57-33-0
Name:
2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-5-(1-methylbutyl)-, sodium salt (1:1)
Superlist Name:
Pentobarbital sodium
Molecular Structure:
Formula:
C₁₁H₁₈N₂NaO₃
Molecular Weight:
249.30
Deleted CAS:
23714-57-0,8050-99-5,8023-11-8,10579-81-4
Synonyms:
Barbituric acid,5-ethyl-5-(1-methylbutyl)-, sodium salt (7CI,8CI);5-Ethyl-5-(1-methylbutyl)barbituric acid sodium salt;Auropan;Biosedan;Diabutal;Ethaminal sodium;Euthanyl;Isobarb;Mebubarbital sodium;Mebumal sodium;Mebunat;Narcoren;Pacifan;Pentobarbitone sodium;Praecicalm;Sagatal;Sodium5-ethyl-5-(1-methylbutyl)barbiturate;Sodium ethaminal;Sodiumpental;Sodium pentobarbitone;Sodium-Pent;Soluble pentobarbital;Sopental;Sotyl;V-Pento;
EINECS:
200-323-9
Solubility:
Soluble in water
Appearance:
Crystalline granules or white powder
Hazard Symbols:
T
Risk Codes:
25
Safety:
45 Details
Transport Information:
UN 2811 6.1/PG 3

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Reference

Postmortem evaluation of barbiturate intoxication: Postmortem evaluation of barbiturate intoxication. Schmoldt, A.; Beckmann, E. R.; Horstmann, W. (Inst. Rechtsmed., Univ. Hamburg, Hamburg D-2000/54, Fed. Rep. Ger.). Z. Rechtsmed., 93(1), 33-41 (German) 1984. CODEN: ZRMDAN. ISSN: 0044-3433. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Chronic abuse of secobarbital [76-73-3], cyclobarbital [52-31-3], brallobarbital [561-86-4], and(or) pentobarbital [57-33-0] induced hypertrophy of smooth endoplasmic reticulum in hepatocytes of humans and lab. animals. Similar liver changes were not obsd. after acute barbiturate overdosing (without prior abuse) or after chronic opiate abuse. Thus, barbiturate tolerance can be evaluated postmortem by light microscopic examn. of the liver.

Cellular lesions in the central nervous system of Periplaneta americana following insecticide treatment in vitro and in vivo: Cellular lesions in the central nervous system of Periplaneta americana following insecticide treatment in vitro and in vivo. I. Nerve cell bodies and the neuropile. Singh, Gur Jai Pal; Singh, Betty (Res. Cent., Agric. Canada, London, ON N6A 5B7, Can.). Neurobehav. Toxicol. Teratol., 6(3), 201-13 (English) 1984. CODEN: NTOTDY. ISSN: 0275-1380. DOCUMENT TYPE: Journal CA Section: 5 (Agrochemical Bioregulators) Cellular lesions in the metathoracic ganglion of P. americana following insecticide treatment have been examd. Treatment of the isolated ganglia with dieldrin [60-57-1] (10 mM) and bioresmethrin [28434-01-7] (5 mM) induced mitochondrial damage in the neuropile and nerve cell bodies. The mitochondria in treated nerve cells were swollen with broken cristae and devoid of normal morphol. appearance. Following in vivo treatment of cockroaches with these insecticides, this type of mitochondrial damage was obsd. even at the onset of poisoning. In the prostrate cockroaches, however, the mitochondrial swelling was accompanied by the accumulation of electron-dense granules. In addn., the neuropiles of insecticide-treated ganglia contained secondary lysosomes which increased in size and no. with the progress of poisoning and showed signs of depletion of synaptic vesicles. The action of dieldrin upon the ultrastructure was completely abolished by pretreatment of ganglia with 10 mM Mg2+. On the other hand, pretreatment of ganglia with tetrodotoxin [4368-28-9] and pentobarbital sodium [57-33-0] had very little effect on the action of dieldrin, though these compds. blocked the action of bioresmethrin. Apparently cellular lesions in the insect central nervous system (CNS), caused by dieldrin, are due to an enhanced uptake of Ca into nerve terminals which may occur independent of membrane depolarization. The effects of bioresmethrin upon the ultrastructure of the CNS are apparently mediated by nerve excitation and membrane depolarization. Thus, treatment of intact cockroaches with dieldrin and bioresmethrin initiates catabolic processes in the nerve cells leading to cellular lesions which are indicative of neuronal degeneration.

Detail of "57-33-0"

2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-5-(1-methylbutyl)-, sodium salt (1:1)

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