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CAS No.: | 57-37-4 |
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Name: | BENACTYZINE HYDROCHLORIDE |
Molecular Structure: | |
Formula: | C20H25 N O3 . Cl H |
Molecular Weight: | 363.884 |
Synonyms: | Benzeneaceticacid, a-hydroxy-a-phenyl-, 2-(diethylamino)ethyl ester,hydrochloride (9CI); Benzilic acid, 2-(diethylamino)ethyl ester hydrochloride(6CI,8CI); Ethanol, 2-diethylamino-, benzilate-HCl (4CI); 2-Diethylaminoethylbenzilate hydrochloride; 2-Diethylaminoethyl diphenylglycolate hydrochloride;AY 5406; AY 5406-1; Actozine; Aktozin; Amisyl; Amitakon; Amizil; Amizyl;Amyzyl; Arcadine; Arkadin; Benactyzine chloride; Benactyzine hydrochloride;Benaktin; Cafron; Cedad; Cevanol; Destendo; Fobex; Ibiotyzil; Katron; Leucidil;Lucidil; Nervacton; Nervatil; Neuraktil; Neurobenzil; Neuroleptone; Nutinal;Parasan; Parazan; Parpon; Phobex; Procalm; Prokalm; Stoikon; Suavitil;Tranquillin; Valladan; Valladon; Win 5606; b-Diethylaminoethyl benzilate hydrochloride |
EINECS: | 200-324-4 |
Density: | 1.115g/cm3 |
Melting Point: |
177-179 °C(lit.) |
Boiling Point: | 409.3°Cat760mmHg |
Flash Point: | 201.4°C |
Hazard Symbols: | |
Risk Codes: | R23/24/25 |
Safety: | Poison by ingestion, intraperitoneal, subcutaneous, intradermal, and intravenous routes. Human systemic effects by ingestion of very small amounts: toxic psychosis. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and HCl. |
Transport Information: | UN 2811 |
PSA: | 49.77000 |
LogP: | 3.60950 |
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IUPAC Name: 2-Diethylaminoethyl 2-hydroxy-2,2-diphenylacetate hydrochloride
Synonyms: 2-(diethylamino)-ethanobenzilatehydrochloride ; 2-(Difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid ; 2-Diethylaminoethylesterkyselinybenzilovehydrochlorid ; Aktozin ; Amisyl ; Amitakon ; Amizil ; Arkadin
Molecular Structure of Benzilic acid-β-diethylaminoethyl ester hydrochloride (CAS NO.57-37-4) :
Molecular Formula of Benzilic acid-β-diethylaminoethyl ester hydrochloride (CAS NO.57-37-4) : C20H25NO3.HCl
Molecular Weight of Benzilic acid-β-diethylaminoethyl ester hydrochloride (CAS NO.57-37-4) : 363.88
CAS NO: 57-37-4
EINECS: 200-324-4
Mol File: 57-37-4.mol
Merck : 1029
Flash Point: 201.4 °C
Enthalpy of Vaporization: 69.75 kJ/mol
Boiling Point: 409.3 °C at 760 mmHg
Vapour Pressure: 1.96E-07 mmHg at 25°C
Melting point: 177-179 ºC
Appearance:White or almost white crystalline powder
SolubilitySoluble in water 14.9g in 100ml at 25°C, practically insoluble in ether
Benzilic acid-β-diethylaminoethyl ester hydrochloride (CAS NO.57-37-4) is usd as anticholinergics.
By reaction of diphenyl glycolic acid with 1 - chloro -2 Diethylamino ethane . Methylbenzene, benzilic acid and 1 - chloro -2 - diethylamino-ethane in the reaction pot and heat, reflux 3h, cooling crystallization, Lut filter , the refining of crude is Benzilic acid-β-diethylaminoethyl ester hydrochloride (CAS NO.57-37-4) .
1. | orl-hmn TDLo:14 µg/kg:CNS | 27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,363. | ||
2. | orl-rat LD50:184 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 1 (1959),42. | ||
3. | ipr-rat LD50:100 mg/kg | APTOA6 Acta Pharmacologica et Toxicologica. 11 (1955),405. | ||
4. | orl-mus LD50:160 mg/kg | 27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,363. | ||
5. | ipr-mus LD50:76 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 74 (1942),274. | ||
6. | scu-mus LD50:250 mg/kg | 27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,363. | ||
7. | ivn-mus LD50:14,300 µg/kg | 28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku ,Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,253. | ||
8. | idr-mus LD50:350 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 59 (1938),149. | ||
9. | ipr-rbt LD50:100 mg/kg | APTOA6 Acta Pharmacologica et Toxicologica. 11 (1955),405. | ||
Reported in EPA TSCA Inventory.
Poison by ingestion, intraperitoneal, subcutaneous, intradermal, and intravenous routes. Human systemic effects by ingestion of very small amounts: toxic psychosis. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and HCl.
Hazard CodesT
Risk Statements 23/24/25
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements 36/37/39-45
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS DD2800000
HazardClass 6.1(b)
PackingGroup III