CAS No.57-41-0,5,5-Diphenylhydantoin Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	57-41-0
Name:	5,5-Diphenylhydantoin
Article Data:	79

Formula:	C₁₅H₁₂N₂O₂
Molecular Weight:	252.272
Synonyms:	Hydantoin,5,5-diphenyl- (8CI);5,5-Diphenyl-1H-imidazolidine-2,4-dione;5,5-Diphenyl-2,4-imidazolidinedione;Aleviatin;DPH;Di-Lan;Dilabid;Dintoina;Diphantoin;Diphedan;Diphenat;Diphenylan;Ekko;Hidantal;Hydantol;Lehydan;NSC 8722;Phenytoin;Phenytoine;Sodanton;Zentropil;
EINECS:	200-328-6
Density:	1.258 g/cm³
Melting Point:	293-295 °C(lit.)
Boiling Point:	428.2°C at 760 mmHg
Flash Point:	11°C
Solubility:	<0.01 g/100 mL at 19 °C in water
Appearance:	white crystals or powder
Hazard Symbols:	T, Xn, F
Risk Codes:	45-61-22-63-40-39/23/24/25-23/24/25-11-20/21/22
Safety:	53-45-36/37-16-7
Transport Information:	UN 2811
PSA:	58.20000
LogP:	2.42720

Synthetic route

: 1097-57-0
ethyl 3-(5,5-diphenylhydantoin) formate

: 57-41-0
phenythoin

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol Heating;	100%

: 21083-47-6
5,5-diphenyl-2-thioxoimidazolidin-4-one

: 57-41-0
phenythoin

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium hydrogencarbonate at 24℃; for 0.5h;	100%
With tetrabromoglycoluril In ethanol at 40℃; for 0.166667h; Reagent/catalyst; Green chemistry;	99%
With dihydrogen peroxide; acetic acid In water; N,N-dimethyl-formamide at 20℃; for 24h;	92%

: 134-81-6
benzil

: 57-13-6
urea

: 57-41-0
phenythoin

Conditions

Conditions	Yield
With potassium hydroxide In ethanol; water at 20℃; for 0.05h; Sonication;	98%
With chitosan decorated Fe3O4 magnetic nanoparticles In ethanol; water at 60℃; for 0.133333h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Green chemistry;	98%
With dmap; potassium hydroxide In water; butan-1-ol at 119℃; for 0.666667h; Temperature;	98.2%

: 134-81-6
benzil

: 57-13-6
urea

A: 5157-15-3
3a,6a-diphenylglycoluril

B: 57-41-0
phenythoin

Conditions

Conditions	Yield
With sodium hydroxide for 0.0333333h; Microwave irradiation; neat (no solvent);	A 1.6% B 98%
With potassium hydroxide In ethanol at 40℃; for 2h; Ultrasound irradiation;	A 75% B 14%
With potassium hydroxide In methanol at 64.84℃; for 24h;	A n/a B 61%

...Expand

: 1-(Aminoacetyl)-5,5-diphenylimidazolidine-2,4-dione hydrochloride

: 57-41-0
phenythoin

Conditions

Conditions	Yield
With hydrogenchloride for 2h; Heating;	93%
Multi-step reaction with 3 steps 1: 55 percent / 4 h / Heating 2: 71 percent / conc. aq. NH3 / ethanol / 24 h / Ambient temperature 3: 63 percent / 2percent aq. HCl / ethanol / 50 h / Heating View Scheme

: 134-81-6
benzil

: 57-41-0
phenythoin

Conditions

Conditions	Yield
With urea; sodium hydroxide In ethanol; water at 80℃; for 3h; Temperature; Large scale;	91.4%

: 120-89-8
parabanic acid

: 71-43-2
benzene

: 57-41-0
phenythoin

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid at 100℃; for 2h;	87%

: 1097-57-0
ethyl 3-(5,5-diphenylhydantoin) formate

A: 1224-08-4
3-amino-5,5-diphenylimidazolidine-2,4-dione

B: 57-41-0
phenythoin

Conditions

Conditions	Yield
With hydrazine hydrate at 130 - 140℃; for 4h;	A 9% B 86%

: potassium cyanide

: 119-61-9
benzophenone

: 506-87-6
ammonium carbonate

: 57-41-0
phenythoin

Conditions

Conditions	Yield
In ethanol; water Heating;	85%
With iron(III) oxide In neat (no solvent) at 70℃; for 0.9h; Bucherer-Bergs Reaction;	85%
In ethanol; water for 0.166667h; Time; Bucherer-Bergs Reaction; Microwave irradiation;	84%
In ethanol at 60℃; for 15h;

...Expand

: 1118-02-1
trimethylsilyl isocyanate

: 93504-24-6
α,α-diphenylglycine methyl ester hydrochloride

: 57-41-0
phenythoin

Conditions

Conditions	Yield
Stage #1: trimethylsilyl isocyanate; α,α-diphenylglycine methyl ester hydrochloride In water for 8h; Milling; Green chemistry; Stage #2: With caesium carbonate In water Milling; Green chemistry;	84%

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Chemistry

MF: C₁₅H₁₂N₂O₂
MW: 252.27
EINECS: 200-328-6
DIHYDANTOIN,it's melting point is about 293-295 °C(lit.);Water Solubility :less than 0.01 g/100 mL at 19 oC.
Following is the of DIHYDANTOIN:

Uses

DIHYDANTOIN can be used in antiepileptic and antiarrhythmic medicine.

Toxicity Data With Reference

1.	dnd-esc 50 µmol/L	MUREAV Mutation Research. 89 (1981),95.
2.	dni-hmn:lym 360 µmol/L	TXAPA9 Toxicology and Applied Pharmacology. 33 (1975),38.
3.	mnt-mus-ivn 500 µg/kg	MUREAV Mutation Research. 141 (1984),183.
4.	orl-wmn TDLo:1620 mg/kg (female 1-39W post):CAR,TER	JAMAAP JAMA, Journal of the American Medical Association. 244 (1980),1464.
5.	orl-wmn TDLo:730 mg/kg/1Y-C:CAR,BLD	NKGZAE Nippon Ketsueki Gakkai Zasshi. Journal of Japan Haematological Society. 46 (1983),1.
6.	unr-wmn TDLo:1620 mg/kg (female 1-39W post):CAR,TER	JAMAAP JAMA, Journal of the American Medical Association. 244 (1980),1464.
7.	unr-wmn TDLo:1620 mg/kg (female 1-39W post):CAR,TER	LANCAO Lancet. 2 (1980),481.
8.	orl-wmn TD:730 mg/kg/1Y-C:CAR,BLD	NKGZAE Nippon Ketsueki Gakkai Zasshi. Journal of Japan Haematological Society. 43 (1980),711.
9.	orl-chd TD:6023 mg/kg/1Y-C:NEO,BLD,SKN	AJDEBP Australasian Journal of Dermatology. 22 (1981),28.
10.	orl-chd TDLo:3 mg/kg/3W:SKN	CLPTAT &n

RTECS : MU1050000

Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 319.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 13 , 1977,p. 201.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 13 , 1977,p. 201.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Safety Profile

Confirmed carcinogen producing lymphoma, Hodgkin's disease, tumors of the skin and appendages. Experimental carcinogenic and tumorigenic data. A human poison by ingestion. Poison experimentally by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by an unspecified route. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: dermatitis, change in motor activity (specific assay), ataxia (loss of muscle coordination), degenerative brain changes, encephalitis, hallucinations, distorted perceptions, irritability, and jaundice. Human teratogenic effects by ingestion: developmental abnormalities of the central nervous system, cardiovascular (circulatory) system, musculoskeletal system, craniofacial area, skin and skin appendages, eye, ear, other developmental abnormalities. Effects on newborn include abnormal growth statistics (e.g., reduced weight gain), physical abnormalities, other postnatal measures or effects, and delayed effects. Human mutation data reported. A drug for the treatment of grand mal and psychomotor seizures. When heated to decomposition it emits toxic fumes of NO_x.

Hazard Codes T,Xn,F
Risk Statements 45-61-63-40-39/23/24/25-11-20/21/22
Safety Statements 53-45-36/37-16-7