Detail of "57-47-6"

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CAS Number:
57-47-6
Name:
Pyrrolo[2,3-b]indol-5-ol,1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, 5-(N-methylcarbamate), (3aS,8aR)-
Molecular Structure:
Formula:
C15H21 N3 O2
Molecular Weight:
275.39
Synonyms:
Physostigmine(8CI); Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-,methylcarbamate (ester), (3aS,8aR)- (9CI); Pyrrolo[2,3-b]indol-5-ol,1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-;(-)-Eserine; (-)-Physostigmine; Cogmine; Eserine; Esromiotin; MCV 4484; NIH10421; NSC 30782; Physostol
Density:
1.166g/cm³
Melting Point:
102-104 °C(lit.)
Boiling Point:
393.5°Cat760mmHg
Flash Point:
191.8°C
Hazard Symbols:
Toxic by ingestion.
Safety:
A human poison by an unspecified route. Poison experimentally by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: nausea, dyspnea, coma, blood pressure elevation, flaccid paralysis without anesthesia, muscle weakness. Normally administered by injection. Poisoning can occur as a result of a mistake in dosage or due to hypersensitivity of the patient within 5 to 25 minutes after administration. Death usually results from respiratory paralysis. Experimental reproductive effects. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of NO_x. See also CARBAMATES. Details

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Assay:≥98%HPLC Package:20mg;50mg;10...Storage:Store in dry... Application:Analytical S...

physostigmine

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Relationship between the temperature and endocrine changes induced by cholinesterase inhibitors: Relationship between the temperature and endocrine changes induced by cholinesterase inhibitors. Kokka, N.; Clemons, G. K.; Lomax, Peter (Sch. Med., Univ.Some commonly used reagents like 50-22-6 and 9002-62-4 are used in this experiment. California, Los Angeles, CA 90024, USA). Pharmacology, 34(2-3), 74-9 (English) 1987. CODEN: PHMGBN. ISSN: 0031-7012. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Cholinesterase [9001-08-5] inhibitors induce changes in plasma hormones in the rat. Since these compds. induce hypothermia the question has been raised as to whether the endocrine responses are secondary to the fall in core temp. The time course of the changes in temp. and plasma levels of corticosterone [50-22-6], growth hormone [9002-72-6], and prolactin [9002-62-4] were examd. following injection of DFP [55-91-4], soman [96-64-0], or physostigmine [57-47-6]. All 3 cholinesterase inhibitors caused an initial rise in corticosterone; DFP decreased growth hormone; physostigmine reduced prolactin. The time course of the hypothermia after DFP and soman did not correlate with that of the rise in corticosterone. Evidently the hormone changes are not secondary to the temp. change. .

Theta in hippocampal slices: relation to synaptic responses of dentate neurons: Theta in hippocampal slices: relation to synaptic responses of dentate neurons. Konopacki, Jan; Maciver, M. Bruce; Bland, Brian H.In this study， 51-83-2 and 51-84-3 are also used.; Roth, Sheldon H. (Dep. Anim. Physiol., Univ. Lodz, Lodz, Pol.). Brain Res. Bull., 18(1), 25-7 (English) 1987. CODEN: BRBUDU. ISSN: 0361-9230. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The effects of cholinergic agents on isolated dentate neurons were studied to characterize cellular mechanisms underlying carbachol [51-83-2]-induced theta EEG activity. Carbachol, eserine [57-47-6], and acetylcholine [51-84-3] produced a synchronization of slow wave activity (theta) accompanied by depression of perforant path to dentate field potentials. These effects were antagonized by atropine but not d-tubocurarine. Apparently, muscarinic receptors mediate theta activity resulting from a depolarization of dentate neurons. .