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Detail of "57-53-4"

  • CAS Number:
  • 57-53-4
  • Name:
  • 1,3-Propanediol,2-methyl-2-propyl-, 1,3-dicarbamate

  • Superlist Name:
  • Meprobamate
  • Molecular Structure:
  • Formula:
  • C9H18 N2 O4
  • Molecular Weight:
  • 218.29
  • Synonyms:
  • 1,3-Propanediol,2-methyl-2-propyl-, dicarbamate (8CI,9CI); 2,2-Di(carbamoyloxymethyl)pentane;2-Methyl-2-n-propyl-1,3-propanediol dicarbamate;2-Methyl-2-propyl-1,3-propanediol dicarbamate; Amepromat; Amosene; Anastress;Anatimon; Andaxin; Aneural; Ansiatan; Anzil; Apascil; Appetrol; Arcoban;Artolon; Atraxin; Ayeramate; Bamo 400; Biobamat; Biobamate; Calmax; Calmiren;Canquil-400; Cap-O-Tran; Carb-A-Med; Carbamic acid2-methyl-2-propyltrimethylene ester; Carbaxin; Cirpon; Crestanil; Cyrpon;Dicandiol; Diron; Ecuanil; Epikur; Equanil; Equanil Suspension; Equinil;Fas-Cile 200; Gadexyl; Harmonin; Hartol; Holbamate; Kesso-Bamate; Klort;Larten; Lepetown; Libiolan; Mar-Bate; Mepantin; Mepavlon; Meposed; Mepr;Meprin; Meprindon; Meprobam; Meprobamat; Meprobamat-Petrasch; Meprobamate;Meproban; Meprocompren; Meprocon CMC; Meprol; Mepronil; Meprosin; Meprospan;Meprotabs; Meprotan; Meproten; Meprotil; Meptran; Mesmar; Metranquil;Micrainin; Microbamat; Milprem; Miltaun; Miltown; Miltrate; Morbam; My-trans;NSC 30418; Nervonus; Oasil; PMB 200; PMB 400; Panediol; Perequil; Perquietil;Pertranquil; Placidon; Placitate; Probamyl; Procalmadiol; Procalmidol; Promate;Protran; Quaname; Quanil; Rastenil; Reostral; Restenil; Robamate; Sedanil;Sedazil; Seril; Setran; Sowell; Tamate; Trankvilan; Tranlisant; Tranquilan;Tranquilax; Tranquiline; Urbil; Urbilat; Vio-Bamate
  • EINECS:
  • 200-337-5
  • Density:
  • 1.139g/cm3
  • Melting Point:
  • 104 - 106 C
  • Boiling Point:
  • 434.2°Cat760mmHg
  • Flash Point:
  • 229.7°C
  • Solubility:
  • negligible
  • Appearance:
  • white crystalline powder
  • Hazard Symbols:
  • Risk Codes:
  • R22   
  • Safety:
  • Human poison by unspecified routes. Moderately toxic to humans and experimentally by ingestion. Experimental poison by intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: coma, blood pressure decrease, regional or general arteriolar constriction, dyspnea, cyanosis, respiratory depression, nausea or vomiting, and allergic skin dermatitis. Experimental reproductive effects. Mutation data reported. Implicated in aplastic anemia. Used as a tranquilizer. When heated to decomposition it emits toxic fumes of NOx. See also CARBAMATES. Details

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CAS No.57-53-4 Meprobamate

Supplier:K.-W.Pfannenschmidt GmbH [ Germany]

600Integral
600

Tel:+49-40-5558660

Address:Habichthorst 34-36 22459 Hamburg

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Reference

Direct titration of amides in non-aqueous medium
Direct titration of amides in non-aqueous medium. I. Determination of some carbamates. Zdunska, Alina; Kwapiszewski, Wincenty; Dulowska, Beata (Inst. Drug Sci., Acad. Med., Warsaw, Pol.). Chem. Anal. (Warsaw), 21(3), 681-6 (Polish) 1976. CODEN: CANWAJ. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Weak bases, meprobamate [57-53-4], carisoprodol [78-44-4], methocarbamol [532-03-6], and phenprobamate [673-31-4] were dissolved in Ac2O and titrated with 0.1N HCl04 in AcOH. The end-point was detected potentiometrically by using a glass electrode (pretreated in Ac2O) and a Ag/AgCl electrode immersed in a satd. KCl soln. in AcOH.In this experiment, several chemicals are used like 673-31-4 and 78-44-4 Titrn. of meprobamate gave one potential jump which corresponded to addn. of 2 H+. .
Problems posed by the selection of a strain of mice for studying antianxiety drugs
Problems posed by the selection of a strain of mice for studying antianxiety drugs. Rambert, Francis A.; Amalvit, Suzanne; Duteil, Jacques (Lab. L. Lafon, Cent. Rech., Maisons-Alfort, Fr.). J. Pharmacol. 604-75-1 and 439-14-5 are also in the experiment., 7(4), 517-30 (French) 1976. CODEN: JNPHAG. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Meprobamate [57-53-4] administered to mice had identical antianxiety activity among different strains of mice regardless of testing methods employed; by contrast, diazepam (I) [439-14-5] and oxazepam [604-75-1] gave varying sedative activities. Strain dependent differences may be explained by the differences in the metabolic rates of these drugs, animals emotionality, and susceptibility to drugs. .
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