57-53-4

Empirical Formula: C₉H₁₈N₂O₄
Molecular Weight: 218.2502 
EINECS: 200-337-5 
Index of Refraction: 1.479
Density: 1.139 g/cm³
Flash Point: 229.7 °C
Storage temp: 2-8°C
Enthalpy of Vaporization: 69.03 kJ/mol
Boiling Point: 434.2 °C at 760 mmHg
Vapour Pressure: 9.64E-08 mmHg at 25 °C
Structure of Meprobamate (CAS NO.57-53-4):
             

 Meprobamate (CAS NO.57-53-4) was first synthesized by Bernard John Ludwig, PhD, and Frank Milan Berger, MD, at Carter Products in May 1950. And, it rapidly became the first blockbuster psychotropic drug in American history, gaining notoriety for its seemingly miraculous effects and becoming popular in Hollywood. In the mid-1940s, Dr. Berger was working in a laboratory of a British drug company for looking for a preservative for penicillin. After moving to Wallace Laboratories in New Jersey, Dr. Berger and a chemist, Dr. Bernard Ludwig, synthesized a chemically-related tranquilizing compound, meprobamate, that was able to overcome these three drawbacks. A December 1955 study of 101 patients at the Mississippi State Hospital in Whitfield, Mississippi, found meprobamate useful in the alleviation of "mental symptoms."In April 1965 meprobamate was removed from the list of tranquilizers when experts ruled that the drug was a sedative instead. The significance of meprobamate and the benzodiazepines lies in the fact that these drugs, despite being habit-forming, essentially replaced the widely-used and potentially-lethal class of sedatives.

 Meprobamate (CAS NO.57-53-4) is used as an anxiolytic drug. It can be used as a weak antipsychotic for the treatment of neurosis nervous insomnia.

Take 2 - Methyl-amyl aldehydes with Formaldehyde for the reaction of aldol condensation to get 2 - Methyl -2 - propyl propylene glycol , and then having the reaction withe Phosgene and Ammonia, or with Sodium cyanate and Hydrochloric acid to derive: Meprobamate (CAS NO.57-53-4).

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Human poison by unspecified routes. Moderately toxic to humans and experimentally by ingestion. Experimental poison by intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: coma, blood pressure decrease, regional or general arteriolar constriction, dyspnea, cyanosis, respiratory depression, nausea or vomiting, and allergic skin dermatitis. Experimental reproductive effects. Mutation data reported. Implicated in aplastic anemia. Used as a tranquilizer. When heated to decomposition it emits toxic fumes of NO_x. See also CARBAMATES.
 

Hazard Codes: Xn TF
Risk Statements: 22-39/23/24/25-23/24/25-11 
R11:Highly flammable. 
R22:Harmful if swallowed. 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed. 
R39:Danger of very serious irreversible effects.
Safety Statements: 7-16-36/37-45 
S7:Keep container tightly closed. 
S16:Keep away from sources of ignition. 
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

 Meprobamate ,its cas register number is 57-53-4. It also can be called Miltown ; Equanil ; Meprospan ; Tranmep and 1,3-Propanediol, 2-methyl-2-propyl-, dicarbamate . It was the best-selling minor tranquilizer for a time, but has largely been replaced by the benzodiazepines. It is a carbamate derivative. Although it was the best-selling minor tranquilizer for a time, it has largely been replaced by the benzodiazepines. Meprobamate has most of the pharmacological effects and dangers of the barbiturates and is licensed for the short-term relief of anxiety, although it is not known whether the purported anti-anxiety effects of meprobamate are separable from its sedative effects.