Reference

Pharmacological study of the effects of some oral contraceptive drugs on certain aspects of carbohydrate metabolism in normal rats

Pharmacological study of the effects of some oral contraceptive drugs on certain aspects of carbohydrate metabolism in normal rats. Khayyal, M. T.; El-Sayed, M. E.; Ahmed, H. M. S.; Ata, M. M. (Fac. Pharm., Cairo Univ., Cairo, Egypt). Egypt. J. Pharm. Sci., 16(2), 197-203 (English) 1975. CODEN: EJPSBZ. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) In normal rats, treatment with ethynylestradiol [57-63-6], norgestrel [6533-00-2], or Primovlar [8056-51-7] had no significant effect on carbohydrate metab. There were transient effects on plasma insulin-like activity [61912-98-9], liver insulinase [9013-83-6] activity, and liver glycogen [9005-79-2] content. These transient effects were reversed upon cessation of contraceptive treatment.

Interaction of rifampicin treatment with pharmacokinetics and metabolism of ethinylestradiol in man

Interaction of rifampicin treatment with pharmacokinetics and metabolism of ethinylestradiol in man. Bolt, H. M.; Bolt, M.; Kappus, H. (Inst. Toxikol., Univ. Tuebingen, Tuebingen, Ger.). Acta Endocrinol. (Copenhagen), 85(1), 189-97 (English) 1977. CODEN: ACENA7. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 1 Tritiated ethinylestradiol (I) [57-63-6] (50 .mu.g) was administered intravenously to volunteers and the free extractable I in the plasma was measured. I showed a biphasic plasma decline. The half-life of the 2nd phase was 7.5 h. Administration of rifampicin (II) [13292-46-1] (l00 mg for 6 days) shifted the half-life of I to 3.3 h, whereas the apparent vol. of distribution for the 2nd phase of elimination was not changed. When I-2,4,6,7-3H] (100 .mu.g) was administered orally, some of the tritium was released by oxidative metab. from the steroid and transformed to tritiated water (HTO) which equilibrated with whole body water. This portion, normally 7.17% of the tritium dose, was increased by previous admistration of II to 10.62%. The initial rate of oxidn. of I-2,4,6,n-3H1 was increased more than 2-fold by II treatment. The results are consistent with previous findings that II induces estrogen-2-hydroxylase in the endoplasmic reticulum of human liver, and explain the decreased effectiveness of I in oral conraceptives, if the patients are treated with II.