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CAS No.: | 57-74-9 |
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Name: | CHLORDANE |
Article Data: | 8 |
Molecular Structure: | |
Formula: | C10H6 Cl8 |
Molecular Weight: | 409.782 |
Synonyms: | 4,7-Methanoindan,1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro- (6CI,8CI);1,2,4,5,6,7,10,10-Octachloro-4,7,8,9-tetrahydro-4,7-endomethyleneindane;1,2,4,5,6,7,10,10-Octachloro-4,7,8,9-tetrahydro-4,7-methyleneindane;1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetrahydroindane;CD 68;Chlorindan;Cortilan-neu;Dowchlor;ENT 9932;HCS 3260;M 140;NSC 8931;Octachloro-4,7-methanotetrahydroindane;Oktaterr;Tat Chlor 4;Toxichlor; |
EINECS: | 200-349-0 |
Density: | 1.75g/cm3 |
Melting Point: | 106 - 107 C |
Boiling Point: | 449.2°Cat760mmHg |
Flash Point: | 229.6°C |
Solubility: |
Stability
Toxicology
|
Appearance: | off-white powder |
Hazard Symbols: | An animal carcinogen. Toxic by ingestion, inhalation, and skin absorption. TLV: 0.5 mg/m3. |
Risk Codes: | 21/22-40-50/53-36/37/38-11-39/23/24/25-23/24/25-67-65-38 |
Safety: | 36/37-60-61-36-33-26-16-45-7-62-29-9 |
PSA: | 0.00000 |
LogP: | 5.68280 |
IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 53 , 1991,p. 115.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 53 , 1991,p. 115.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 53 , 1991,p. 115.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .
The Chlordane, with the CAS registry number 57-74-9,is also known as CD 68; 1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetrahydroindane. It belongs to the product categories of Method Specific;Oeko-Tex Standard 100;PesticidesMethod Specific. This chemical's molecular formula is C10H6Cl8 and molecular weight is 409.78. Its EINECS number is 200-349-0.What's more,Its systematic name is Chlordane.It is a off-white powder which is stable, but readily decomposed by moderately strong alkaline solutions. Corrodes iron and zinc and attacks some types of polymer. Incompatible with strong oxidizing agents.It is used as a pesticide. This white solid was sold in the U.S. until 1983 as an insecticide for crops like corn and citrus and on lawns and domestic gardens.
Physical properties about Chlordane are:
(1)ACD/LogP: 5.893; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 5.89; (4)ACD/LogD (pH 7.4): 5.89; (5)ACD/BCF (pH 5.5): 17718.95; (6)ACD/BCF (pH 7.4): 17718.95; (7)ACD/KOC (pH 5.5): 38248.88; (8)ACD/KOC (pH 7.4): 38248.88; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Index of Refraction: 1.627; (13)Molar Refractivity: 80.279 cm3; (14)Molar Volume: 226.463 cm3; (15)Surface Tension: 54.1319999694824 dyne/cm; (16)Density: 1.809 g/cm3; (17)Flash Point: 212.488 °C; (18)Enthalpy of Vaporization: 65.292 kJ/mol; (19)Boiling Point: 424.685 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES:Cl/C2=C(\Cl)C3(Cl)C1CC(Cl)C(Cl)C1C2(Cl)C3(Cl)Cl;
(2)Std. InChI:InChI=1S/C10H6Cl8/c11-3-1-2-4(5(3)12)9(16)7(14)6(13)8(2,15)10(9,17)18/h2-5H,1H2;
(3)Std. InChIKey:BIWJNBZANLAXMG-UHFFFAOYSA-N.
The toxicity data of Chlordane as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
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cat | LC50 | inhalation | 100mg/m3/4H (100mg/m3) | behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold behavioral: excitement | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 8(4), Pg. 30, 1964. |
chicken | LD50 | oral | 220mg/kg (220mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 226, 1966. | |
domestic animals - goat/sheep | LD50 | oral | 50mg/kg (50mg/kg) | Yakkyoku. Pharmacy. Vol. 32, Pg. 471, 1981. | |
duck | LD50 | oral | 1200mg/kg (1200mg/kg) | Down to Earth. Vol. 35, Pg. 25, 1979. | |
hamster | LD50 | oral | 1720mg/kg (1720mg/kg) | European Journal of Toxicology and Environmental Hygiene. Vol. 7, Pg. 159, 1974. | |
human | LDLo | oral | 29mg/kg (29mg/kg) | liver: fatty liver degeration | "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956Vol. -, Pg. 1, 1956. |
human | LDLo | skin | 428mg/kg (428mg/kg) | behavioral: tremor behavioral: convulsions or effect on seizure threshold behavioral: ataxia | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 648, 1969. |
mammal (species unspecified) | LC50 | inhalation | > 20gm/m3/4H (20000mg/m3) | Pesticide Manual. Vol. 9, Pg. 139, 1991. | |
mammal (species unspecified) | LD50 | oral | 180mg/kg (180mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 226, 1966. | |
man | LDLo | unreported | 118mg/kg (118mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
man | TDLo | oral | 3071ug/kg (3.071mg/kg) | behavioral: coma lungs, thorax, or respiration: dyspnea gastrointestinal: nausea or vomiting | Journal of Toxicology, Clinical Toxicology. Vol. 20, Pg. 291, 1983. |
mouse | LD50 | intravenous | 100mg/kg (100mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04876, | |
mouse | LD50 | oral | 145mg/kg (145mg/kg) | Agricultural Research Service, USDA Information Memorandum. Vol. 20, Pg. 19, 1966. | |
mouse | LDLo | intraperitoneal | 240mg/kg (240mg/kg) | Toxicology and Applied Pharmacology. Vol. 23, Pg. 288, 1972. | |
rabbit | LD50 | oral | 100mg/kg (100mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 226, 1966. | |
rabbit | LD50 | skin | 780mg/kg (780mg/kg) | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976. | |
rabbit | LDLo | intravenous | 10mg/kg (10mg/kg) | Archives of Industrial Hygiene and Occupational Medicine. Vol. 1, Pg. 13, 1950. | |
rat | LD50 | intraperitoneal | 343mg/kg (343mg/kg) | Toxicology and Applied Pharmacology. Vol. 32, Pg. 443, 1975. | |
rat | LD50 | oral | 200mg/kg (200mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 614, 1967. | |
rat | LD50 | skin | 690mg/kg (690mg/kg) | Journal of the American Veterinary Medical Association. Vol. 157, Pg. 1835, 1970. | |
women | LDLo | oral | 120ug/kg (0.12mg/kg) | behavioral: convulsions or effect on seizure threshold behavioral: excitement gastrointestinal: gastritis | "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956Vol. -, Pg. 1, 1956. |