Reference

Effect of hormonal treatments prior to lactation on hormones in blood plasma, milk, and urine during early lactation

Effect of hormonal treatments prior to lactation on hormones in blood plasma, milk, and urine during early lactation. Erb, R. E.; Chew, B. P.; Keller, H. F.; Malven, P. V. (Dep. Anim. Sci., Purdue Univ., West Lafayette, Indiana, USA). J. Dairy Sci., 60(4), 557-65 (English) 1977. CODEN: JDSCAE. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 13 Hormonal changes in blood plasma, colostrum, milk, and urine were studied through day 25 of lactation in 6, 6, and 2 Holsteins, resp., to compare normal calving, premature calving induced with 25 mg of dexamethasone [50-02-2] and 17.beta.-estradiol [50-28-2], and lactation induced with exogenous 17.beta.-estradiol and progesterone [57-83-0]. Treatments had no effect on concns. of prolactin [9002-62-4] in plasma, but concns. and daily excretion (.mu.g/day) of prolactin were higher in milk after induced calving. Concns. of prolactin in colostrum were up to 8 times higher than in blood plasma and decreased subsequently to near ratios of 1:1 in milk. Hormonal treatments had no effect on progesterone in plasma, colostrum, or milk. Major differences in the estrogens (estrone [53-16-7], 17.beta.-estradiol, 17.alpha.-estradiol [57-91-0], and their total) were obsd. after day 2 of lactation. Concns. of the estrogens in plasma and milk, and rates of excretion in urine and milk were lower 3 days after normal calving than after induced calving. Postpartum, estrone decreased proportionately more in milk than 17.alpha.-estradiol. Proportions of each estrogen in mammary secretions resembled those in blood plasma prior to day 3 of lactation (estrone major) and those in urine thereafter (17.alpha.-estradiol major). Concns. of 17.alpha.-estradiol in milk were 3-10-fold higher, but total estrogen was only .apprx.2-fold higher than in blood plasma.

Effects of gonadal hormones on hyaluronic acid content in male mouse skin

Effects of gonadal hormones on hyaluronic acid content in male mouse skin. Usui, Yukio; Kanke, Yusuke; Mori, Yo (Dep. Biochem., Tokyo Coll. Pharm., Tokyo, Japan). Endocrinol. Jpn., 24(4), 399-402 (English) 1977. CODEN: ECJPAE. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Male mice were injected with several gonadal hormones daily for 5 days in order to study their effects on hyaluronic acid (I) [9004-61-9] content in the skin. Hormones increased total hexosamine and I contents in the following order: 17.beta.-estradiol (II) [50-28-2] (10 .mu.g) > 17.alpha.-estradiol [57-91-0] (100 .mu.g) > testosterone [58-22-0] (100 .mu.g) > control. Testosterone (100 .mu.g) or 5.alpha.-dihydrotestosterone [521-18-6] (100 .mu.g) injected with II (10 .mu.g) blocked the increase in I content produced by II. Apparently, the increase in I is not specific for II and the action of testosterone or 5.alpha.-dihydrotestosterone is antagonistic to that of II in the male mouse skin.