CAS No.57044-25-4,(R)-(+)-Glycidol Suppliers

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Basic Information

Molecular Structure:
CAS No.:	57044-25-4
Name:	(R)-(+)-Glycidol
Article Data:	46

Formula:	C₃H₆O₂
Molecular Weight:	74.0794
Synonyms:	Oxiranemethanol, (2R)- (9CI);Oxiranemethanol,(R)-;(+)-2,3-Epoxy-1-propanol;(+)-Glycidol;(2R)-2-Oxiranylmethanol;(R)-2-Oxiranylmethanol;(R)-Glycidol;(R)-Oxiran-2-ylmethanol;2(R)-2,3-Epoxypropanol;
EINECS:	209-128-3
Density:	1.178 g/cm³
Boiling Point:	162.4 °C at 760 mmHg
Flash Point:	81.1 °C
Solubility:	Completely miscible in water
Appearance:	Colorless to light yellow liquid
Hazard Symbols:	T, E
Risk Codes:	45-60-2-21/22-23-34-68-41-37/38
Safety:	53-45-36/37/39-26
Transport Information:	UN 2922 8/PG 2
PSA:	32.76000
LogP:	-0.62250

Synthetic route

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 57044-25-4
(R)-oxiranemethanol

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane for 18h; Ambient temperature;	88%
With potassium carbonate In dichloromethane other reagent: Cs2CO3;
With potassium phosphate In dichloromethane for 3h; Product distribution / selectivity; Heating / reflux;
With potassium carbonate In dichloromethane at 20℃; for 24h;
With potassium carbonate In dichloromethane at 20℃; for 20h;

: 14437-88-8
(2R)-3-bromo-1,2-propanediol

: 57044-25-4
(R)-oxiranemethanol

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane for 18h; Ambient temperature;	88%

: 107-18-6
allyl alcohol

A: 57044-25-4
(R)-oxiranemethanol

B: 60456-23-7
(S)-oxiranemethanol

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; tantalum pentaethoxide In dichloromethane at 0℃; for 48h; Product distribution / selectivity; Molecular sieve;	A 45% B n/a
With Cumene hydroperoxide; 3 A molecular sieve; titanium(IV) isopropylate; D-(-)-diisopropyl tartrate In dichloromethane at -5℃; for 6h; Title compound not separated from byproducts;
With titanium(IV) isopropylate; L-(+)-diisopropyl tartrate; Cumene hydroperoxide 1.) CH2Cl2, -10 deg C, 20 min, 2.) CH2Cl2, -10 deg C, 5 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

: 2461-40-7
(+/-)-glycidyl butyrate

A: 60456-26-0
(R)-glycidyl butyrate

B: 57044-25-4
(R)-oxiranemethanol

Conditions

Conditions	Yield
With sodium phosphate buffer; 25 kDa lipase-like enzyme immobilized on DEAE-Sepharose In 1,4-dioxane; water at 25℃; for 10h; pH=7.00;	A n/a B 45%
With thermomyces lanuginosa In 1,4-dioxane; aq. phosphate buffer at 30℃; for 2h; pH=7; Temperature; Resolution of racemate; Enzymatic reaction;	A n/a B n/a

: 556-52-5
oxiranyl-methanol

A: 56-81-5
glycerol

B: 57044-25-4
(R)-oxiranemethanol

Conditions

Conditions	Yield
With water; chiral ((substituted salen)Co)2-InCl3 In tetrahydrofuran at 20℃; for 6h;	A n/a B 44%

: 556-52-5
oxiranyl-methanol

A: 56-81-5
glycerol

B: 57044-25-4
(R)-oxiranemethanol

C: 60456-23-7
(S)-oxiranemethanol

Conditions

Conditions	Yield
With water; dimeric chiral (salen)Co complex linked with Al at 20℃; for 4h; Product distribution; Further Variations:; Catalysts;	A 42% B n/a C n/a

...Expand

: 107-18-6
allyl alcohol

: 57044-25-4
(R)-oxiranemethanol

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; D-(-)-diisopropyl tartrate; ((CH3)3CCH2)3Ta=CHC(CH3)3 impergnated on silica; tantal content 4.92percent In dichloromethane at 0℃; for 48h; Product distribution / selectivity;	29%
With L-(+)-diisopropyl tartrate; Cumene hydroperoxide; titanium tetraisopropoxide sublimed on silica; titanium content 1.8percent (C/Ti=6.7) In dichloromethane at 0℃; for 48h; Product distribution / selectivity;	14%
With oxygen In N,N-dimethyl-formamide at 50℃; under 760.051 Torr; for 24h; Catalytic behavior;	12%
Sharpless asymmetric epoxidation;
With titanium(IV) isopropylate; tert.-butylhydroperoxide; calcium hydride; diethyl (2R,3R)-tartrate; silica gel In tetrahydrofuran at -20 - -15℃; for 6h; Temperature; Solvent;

: 556-52-5
oxiranyl-methanol

: 57044-25-4
(R)-oxiranemethanol

Conditions

Conditions	Yield
	19%
enantioselective resolution; CPO-catalysed oxidation with tert-butyl hydroperoxidase;

: 41274-09-3
(R)-3-tosyloxy-1,2-propanediol

: 57044-25-4
(R)-oxiranemethanol

Conditions

Conditions	Yield
With sodium methylate In diethyl ether for 1h;
With sodium methylate In methanol; diethyl ether Yield given;
With sodium In methanol
With sodium methylate In diethyl ether

: 110207-31-3
Pentanoic acid oxiranylmethyl ester

: 57044-25-4
(R)-oxiranemethanol

Conditions

Conditions	Yield
lipase membran-enclosed enzymatic catalysis;

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Chemistry

Product Name: (R)-(+)-Glycidol
The Molecular formula of (R)-Glycidol(57044-25-4): C₃H₆O₂
The Molecular Weight of (R)-Glycidol(57044-25-4): 74.08
Molecular Structure :

EINECS: 404-660-4
Boiling point: 56-57 °C11 mm Hg(lit.)
Flash point: 178 °F
density: 1.116 g/mL at 20 °C(lit.)
refractive index: n20/D 1.43(lit.)
storage temp.: 2-8°C
Appearance: Colorless to light yellow liquid
Synonyms: (R)-GLYCIDOL;OXIRANEMETHANOL, (2R)-;(R)-(+)-2,3-EPOXY-1-PROPANOL;(R)-(+)-GLYCIDOL;(R)-(+)-GLYCIDOL, 97% (98% EE/GLC); R(+)-OXIRANE-2-METHANOL;(R)-Oxiranemethanol; (r)-oxiranemethano;

Uses

(R)-Glycidol(57044-25-4) is used for synthesis pharmaceutical intermediates.

Safety Profile

The Hazard Codes of (R)-Glycidol(57044-25-4): T, E
The Risk Statements information of (R)-Glycidol(57044-25-4):
2: Risk of explosion by shock, friction, fire or other sources of ignition
23: Toxic by inhalation
34: Causes burns
45: May cause cancer
60: May impair fertility
68: Possible risk of irreversible effects
20/21: Harmful by inhalation and in contact with skin
37/38: Irritating to respiratory system and skin
The Safety Statements information of (R)-Glycidol(57044-25-4):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53: Avoid exposure - obtain special instruction before use
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
F: 10-21
RIDADR: UN 2922 8/PG 2
WGK Germany: 3
RTECS: RR0508000