Detail of "57109-90-7"

Reference

The effect of Tranxilium and Rivotril on self-sustained after-discharges in rats

The effect of Tranxilium and Rivotril on self-sustained after-discharges in rats. Heidler, I.; Mares, J.; Mares, P.; Trojan, S. (Med. Fac., Charles Univ., Prague, Czech.). Act. Nerv. Super., 26(1), 61-2 (English) 1984. CODEN: ACNSAX. ISSN: 0001-7604. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In rats, the effect of Tranxilium (I) [57109-90-7] and Rivotril (II) [1622-61-3] on the self-sustained after discharges (SSAD) in the right sensorimotor area of the brain cortex were detd. II blocked the prolongation of cortical SSAD's induced by repeated elec. stimulation. After the first application of I, the SSAD was prolonged, but after subsequent doses, the SSAD's were shorter than after the previous dose.

Bioavailability of different oral dosage forms of clorazepate dipotassium (Tranxene)

Bioavailability of different oral dosage forms of clorazepate dipotassium (Tranxene). Reynier, J. P.; Bovis, A.; Bertocchio, M. H. (Serv. Pharm. Galenique, Fac. Pharm., Marseille F-13385/5, Fr.). Pharm. Acta Helv., 59(7), 191-9 (French) 1984. CODEN: PAHEAA. ISSN: 0031-6865. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 The bioavailability of di-K clorazepate (Tranxene)(I) [57109-90-7] from conventional tablets and capsules and from sustained-release tablets was investigated in 4 patients. The absorption of I was rapid, and the time to reach the max. concn. was 3 h. Elimination, which was total after 12 h, was thus more rapid than that obsd. after i.v. injection (36 h). I undergoes decarboxylation in the digestive tract and the metabolite, N-demethyldiazepam (II) [1088-11-5] has a long half-life and is therefore eliminated slowly. Thus, the new sustained-release tablet formulations do not have advantages over the conventional oral formulations.