Detail of "5719-85-7"

Reference

Determination of phenylbutazone, tolbutamide and metabolites in plasma and urine using chemical ionization mass spectrometry

Determination of phenylbutazone, tolbutamide and metabolites in plasma and urine using chemical ionization mass spectrometry. Weinkam, Robert J.; Rowland, Malcolm; Meffin, Peter J. (Sch. Pharm., Univ. California, San Francisco, Calif., USA). Biomed. Mass Spectrom., 4(1), 42-7 (English) 1977. CODEN: BMSYAL. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Phenylbutazone [50-33-9] and tolbutamide [64-77-7] levels in plasma were detd. by addn. of D labeled internal stds. to plasma followed by extn. and direct sample insertion into a mass spectrometer operating under chem. ionization conditions. Peak height ratios used to calc. plasma levels were detd. by using either selected ion monitoring or repetitive scan data. The scan approach was also used for the simultaneous detn. of tolbutamide and 2 metabolites (hydroxy- [5719-85-7] and carboxytolbutamide [2224-10-4]) from urine. The accuracy, precision, and sensitivity of the direct sample insertion approach to drug level measurement were detd.

Measurement of antidiabetic sulfonylureas in serum by gas chromatography with electron-capture detection

Measurement of antidiabetic sulfonylureas in serum by gas chromatography with electron-capture detection. Braselton, W. Emmett, Jr.; Bransome, Edwin D., Jr.; Huff, Thomas A. (Dep. Med., Med. Coll.Some commonly used reagents like 64-77-7 and 94-20-2 are used in this experiment. Georgia, Augusta, Ga., USA). Diabetes, 26(1), 50-7 (English) 1977. CODEN: DIAEAZ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) A method is described for measurement of chlorpropamide (I) [94-20-2], tolbutamide [64-77-7] and the II metabolites hydroxymethyltolbutamide [5719-85-7] and carboxytolbutamide [2224-10-4] in blood. It consists of formation of the thermally stable methyl-trifluoroacetyl derivs. of I and II, and the methyl-heptafluorobutyryl derivs. of hydroxymethyltolbutamide and carboxytolbutamide, which are then analyzed by electron-capture gas chromatog. Measurements of blood levels of the compds. with this method have been verified by quantitation of the same samples using gas chromatog.-mass spectrometry in the mass fragmentog. mode. Blood level values and .beta.-phase half-time disappearance rates of I, II, hydroxymethyltolbutamide, and carboxytolbutamide were measured in normal volunteers following an oral dose of I or II. Blood levels of the 4 compds. were also detd. in a few diabetics receiving continuous daily treatment. .