Reference

Methylene-bridged bay region chrysene and phenanthrene derivatives and their keto analogs: mutagenicity in Salmonella typhimurium and tumor initiating activity on mouse skin

Methylene-bridged bay region chrysene and phenanthrene derivatives and their keto analogs: mutagenicity in Salmonella typhimurium and tumor initiating activity on mouse skin. Rice, Joseph E.; Makowski, Gregory S.; Hosted, Thomas J., Jr.; Lavoie, Edmond J. (Amer. Health Found., Naylor Dana Inst. Dis. Prev., Valhalla, NY 10595, USA). Cancer Lett. (Shannon, Irel.), 27(2), 199-206 (English) 1985. CODEN: CALEDQ. ISSN: 0304-3835. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) A series of methylene-bridged and keto-bridged bay region derivs. of chrysene and phenanthrene were prepd. and evaluated for mutagenic activity in S. typhimurium TA100 and for tumor-initiating activity on CD-1 mouse skin. The compds. included in this series were 4H-cyclopenta[def]phenanthrene (I) [203-64-5], 4H-cyclopenta[def]phenanthren-4-one [5737-13-3], 1-methyl-4H-cyclopenta[def]phenanthrene [98090-89-2], 1-methyl-4H-cyclopenta[def]phenanthren-4-one [98096-09-4], 4H-cyclopenta[def]chrysene [202-98-2], and 4H-cyclopenta[def]chrysen-4-one [86853-91-0]. Among these compds. only I and 1-methyl-4H-cyclopenta[def]phenanthren-4-one were not significantly mutagenic when assayed with metabolic activation using Aroclor-induced rat liver homogenate. None of the compds. assayed were active without metabolic activation. 4H-Cyclopenta[def]chrysene was the most tumorigenic of the methylene-bridged bay region PAH test on mouse skin. At a dose of 1.0 mg this compd. resulted in 100% of the animals bearing papillomas with 5.63 papillomas/animal. 4H-Cyclopenta[def]chrysen-4-one and 1-methyl-4H-cyclopenta[def]phenanthrene displayed weak tumorigenic activity at a total initiating dose of 1.0 mg.

Carbon black adsorbates: a new carcinogen and oxygenated polycyclics

Carbon black adsorbates: a new carcinogen and oxygenated polycyclics. Gold, Avram (Harvard Sch. Public Health, Boston, Mass., USA). Environ. Aspects Chem. Use Rubber Process.Chemicals with cas numbers 85-01-8 and 5737-13-3 also play role. Oper., Conf. Proc., 137-63. Edited by: Ayer, Franklin A. Off. Toxic Subst., Environ. Prot. Agency: Washington, D. C. (English) 1975. CODEN: 34PYAE. DOCUMENT TYPE: Conference CA Section: 4 (Toxicology) Section cross-reference(s): 38 The polycyclic arom. and polar org. fractions were extd. from carbon black and fractionated by liq. and(or) gas chromatog., and the resulting components were identified by IR, UV, and (or) mass spectrometry. A previously uncharacterized polycyclic arom. hydrocarbon was identified as cyclopenta[cd]pyrene (I) [27208-37-3] by partial hydrogenation and spectroscopic anal. of the product. This carcinogenic compd. appeared to be a major constituent of carbon balck. Most of the compds. identified or partially identified in the neutral polar fraction were not well known, and their carcinogenicity has not been tested. .