Detail of "574-92-5"

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CAS Number:
574-92-5
Name:
3-Quinolinecarboxylicacid, 4-hydroxy-7-(trifluoromethyl)-
Molecular Structure:
Formula:
C11H6 F3 N O3
Molecular Weight:
257.1654
Synonyms:
3-Carboxy-4-hydroxy-7-trifluoromethylquinoline;4-Hydroxy-7-(trifluoromethyl)-3-quinolinecarboxylic acid;7-Trifluoromethyl-4-hydroxyquinoline-3-carboxylic acid
Density:
1.55 g/cm³
Melting Point:
259-260 °C (dec.)(lit.)
Boiling Point:
354.7 °C at 760 mmHg
Flash Point:
168.3 °C
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
26-37/39 Details

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Synthesis and antiinflammatory activity of certain quinoline-3-carboxylic acid derivatives related to flufenamic acid: Synthesis and antiinflammatory activity of certain quinoline-3-carboxylic acid derivatives related to flufenamic acid. Aboul-Enein, H. Y.; Ismail, M.; Ibrahim, S. E. (Coll. Pharm., King Saud Univ., Riyadh, Saudi Arabia). Drugs Exp. Clin. Res., 9(8-9), 585-9 (English) 1983. CODEN: DECRDP. ISSN: 0378-6501. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 Chlorination of hydroxyquinolinecarboxylate I (R = R1 = OH), followed by partial hydrolysis, gave I (R = Cl, R1 = OH). I (R = Cl, R1 = OH) was aminated to give aminoquinolinecarboxylates I (R = NHC6H3ClMe-6,2, NHC6H3ClMe-4,2, NHC6H4CF3-3; R1 = OH), which had antiinflammatory activity. I (R = R1 = OH) inhibited formation of granulomae in rats at 50 mg/kg day for 7 days, giving granulomae of 16.4 ± 0. 574-92-5 and 95-69-2 which are cas registry numbers of substances are two of reagents here.2 mg vs. 25.18 ± 0.21 mg in controls. .