Detail of "577-85-5"

Reference

Reduction of reabsorption effects in scintillators by employing solutes with large Stokes shifts

Reduction of reabsorption effects in scintillators by employing solutes with large Stokes shifts. Renschler, Clifford L.; Harrah, Larry A. (Sandia Natl. Lab., Albuquerque, NM 87185, USA). Nucl. Instrum. Methods Phys. Res., Sect. A, A235(1), 41-5 (English) 1985. CODEN: NIMAER. DOCUMENT TYPE: Journal CA Section: 71 (Nuclear Technology) Section cross-reference(s): 73 Energy transfer losses due to reabsorption effects can lead to reduced light output in scintillators. The advantages of using solutes with very large Stokes shifts to reduce these effects are discussed, and 3-hydroxyflavone [577-85-5] is proposed as 1 such solute. Model scintillators are formulated to test this concept.

Enhancement of the mutagenicity of 2-acetylaminofluorene by flavonoids and the structural requirements

Enhancement of the mutagenicity of 2-acetylaminofluorene by flavonoids and the structural requirements. Ogawa, S.; Hirayama, T.; Sumida, Y.; Tokuda, M.; Hirai, K.; Fukui, S. (Kyoto Pharm. 117-39-5 and 487-26-3 are cas registry numbers. These chemicals are also mentioned in this article. Univ., Kyoto 607, Japan). Mutat. Res., 190(2), 107-12 (English) 1987. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The enhancing effects of 12 flavonoids (I, R and R1 = H, OH; n = m = 0-3) on the mutagenicity of 2-acetylaminofluorene (AAF) [53-96-3] in Salmonella typhimurium TA98 were investigated. In the mixed applications of AAF (22.4 nmol/plate) with I (31.4-45.0 nmol/plate) in the presence of a mammalian metabolic activation system (S9 mix), morin [480-16-0], galangin [548-83-4], flavonol [577-85-5], kaempferol [520-18-3], quercetin [117-39-5], and myricetin [529-44-2] enhanced the mutagenicity of AAF by 3.3-10.2-fold. The potency of the mutagenicity enhancing effects increased in the described order. For the mutagenicity-enhancing effects of the flavonoids on AAF, the flavonol structure, including the 3-OH group and the 2,3-double bond, were essential. In the quercetin analogs, the 5-OH group was also essential. Further, the nos. of the OH groups substituted at the 3', 4', and 5'-positions in the B-ring contributed to an increase of the enhancing effect, whereas the substitution of the OH group at the 2'-position depressed the potency of the effect. .