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| CAS No.: | 57801-81-7 |
|---|---|
| Name: | BROTIZOLAM |
| Article Data: | 6 |
| Molecular Structure: | |
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| Formula: | C15H10 Br Cl N4 S |
| Molecular Weight: | 393.694 |
| Synonyms: | Brotizolam;Lendorm; Lendormin; Mederantil; Sintonal; WE 941; WE 941BS |
| Density: | 1.78g/cm3 |
| Melting Point: | 204-206?C |
| Boiling Point: | 561.3°Cat760mmHg |
| Flash Point: | 293.3°C |
| Safety: | Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of Cl−, Br−, SOx, and NOx. |
| PSA: | 71.31000 |
| LogP: | 3.83970 |
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Chemistry
Product Name: Brotizolam
Synonyms: 2-Bromo-4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine ; 2-Bromo-4-(o-chlorophenyl)-9-methyl-6H-thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepine ; 6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 2-bromo-4-(2-chlorophenyl)-9-methyl- ; 8-Bromo-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[3,4-c]thieno[2,3-e]-1,4-diazepine
CAS NO: 57801-81-7
Molecular Formula of Lendormin (CAS NO.57801-81-7) : C15H10BrClN4S
Molecular Weight of Lendormin (CAS NO.57801-81-7) : 393.69
Molecular Structure of Lendormin (CAS NO.57801-81-7) : 
EINECS: 260-964-5
Mol File: 57801-81-7.mol
Index of Refraction: 1.801
Surface Tension: 63.3 dyne/cm
Density: 1.78 g/cm3
Flash Point: 293.3 °C
Melting point: 212 ~ 214°C.
Enthalpy of Vaporization: 84.42 kJ/mol
Boiling Point: 561.3 °C at 760 mmHg
Vapour Pressure: 1.25E-12 mmHg at 25°C
Uses
Lendormin (CAS NO.57801-81-7) is used for anti-excited, anticonvulsant, and muscle relaxation hypnosis and so on. it is for sleep sleep disorder (not easily back to sleep after midnight and wake up).
Production
Raw materials Dichloromethane-->Chloroform-->Phosphorus pentasulfide-->Triethyl orthoacetate-->Hexamethyleneimine
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | oral | > 100mg/kg (100mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 540, 1986. |
| dog | LD50 | oral | > 2gm/kg (2000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 592, 1986. |
| monkey | LDLo | oral | > 2500ug/kg (2.5mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 540, 1986. |
| mouse | LD50 | intraperitoneal | 920mg/kg (920mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 592, 1986. |
| mouse | LD50 | intravenous | > 20mg/kg (20mg/kg) | Drugs in Japan Vol. -, Pg. 1028, 1990. | |
| mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 592, 1986. |
| pig | LDLo | oral | > 10mg/kg (10mg/kg) | AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 540, 1986. |
| rabbit | LD50 | oral | > 2gm/kg (2000mg/kg) | AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 592, 1986. |
| rat | LD50 | intraperitoneal | > 1gm/kg (1000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 592, 1986. |
| rat | LD50 | intravenous | > 20mg/kg (20mg/kg) | Drugs in Japan Vol. -, Pg. 1028, 1990. | |
| rat | LDLo | oral | 3456mg/kg (3456mg/kg) | BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 540, 1986. |
Safety Profile
Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of Cl−, Br−, SOx, and NOx.