CAS No.57808-65-8,Closantel Suppliers

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Basic Information

Molecular Structure:
CAS No.:	57808-65-8
Name:	Closantel
Article Data:	2

Formula:	C₂₂H₁₄Cl₂I₂N₂O₂
Molecular Weight:	663.08
Synonyms:	NSC 335306;Zycloz;
EINECS:	260-967-1
Density:	1.943 g/cm³
Melting Point:	210 - 22oC
Boiling Point:	590.5 °C at 760 mmHg
Flash Point:	310.9 °C
Appearance:	white to yellowish powder
Hazard Symbols:	Xn
Risk Codes:	22
Transport Information:	UN 2811
PSA:	73.12000
LogP:	7.19738

Synthetic route

: 61437-85-2
2-(4-amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile

2-hydroxy-3,5-diiodobenzoyl derivative: 2-hydroxy-3,5-diiodobenzoyl derivative

: 57808-65-8
closantel

Conditions

Conditions	Yield
In toluene at 50℃; for 6h; Solvent; Reflux; Sealed tube;	89.1%

: 123-91-1
1,4-dioxane

: 42016-91-1
2-hydroxy-3,5-diiodobenzoyl chloride

: 61437-85-2
2-(4-amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile

: 57808-65-8
closantel

...Expand

: 140-53-4
p-chlorobenzyl cyanide

: 57808-65-8
closantel

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium methylate; methanol / 3 h / 50 °C / Sealed tube 2: hydrazine hydrate; sodium hydroxide / diethylene glycol / 6 h / 200 °C / Sealed tube 3: toluene / 6 h / 50 °C / Reflux; Sealed tube View Scheme

: 89-59-8
4-chloro-2-nitrotoluene

: 57808-65-8
closantel

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium methylate; methanol / 3 h / 50 °C / Sealed tube 2: hydrazine hydrate; sodium hydroxide / diethylene glycol / 6 h / 200 °C / Sealed tube 3: toluene / 6 h / 50 °C / Reflux; Sealed tube View Scheme

: 844-24-6
4-chloro-α-(2-chloro-4-hydroxyimino-5-methyl-2,5-cyclohexadien-1-ylidene)phenylacetonitrile

: 57808-65-8
closantel

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrazine hydrate; sodium hydroxide / diethylene glycol / 6 h / 200 °C / Sealed tube 2: toluene / 6 h / 50 °C / Reflux; Sealed tube View Scheme

: 57808-65-8
closantel

: closantel sodium salt

Conditions

Conditions	Yield
With sodium hydroxide In water at 70℃; for 6h; Sealed tube;	99.3%

: 78-96-6, 1674-56-2
3-amino-2-propanol

: 57808-65-8
closantel

: isopropanolamine closantel salt

Conditions

Conditions	Yield
In tetrahydrofuran; acetonitrile

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 57808-65-8
closantel

: N-methylglucamine salt of closantel

Conditions

Conditions	Yield
In propylene glycol; ethanol; benzyl alcohol

: 111-42-2
2,2'-iminobis[ethanol]

: 57808-65-8
closantel

: diethanolamine closantel salt

Conditions

Conditions	Yield
In propylene glycol; ethanol; benzyl alcohol

: 141-43-5
ethanolamine

: 57808-65-8
closantel

: closantel ethanolamine salt

Conditions

Conditions	Yield
In ethoxyethoxyethanol
In 2-pyrrolidinon; polypropylene glycol 400; benzyl alcohol

Raw Materials

42016-91-1

61437-85-2

123-91-1

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Chemistry

The Molecular formula of N-(5-CHLORO-4-((4-CHLOROPHENYL) CYANOMETHYL)-2-METHYLPHENYL)-2-HYDROXY-3, 5-DIIODOBENZAMIDE（57808-65-8）：C₂₂H₁₄C_l2I₂N₂O₂
The Molecular Weight of N-(5-CHLORO-4-((4-CHLOROPHENYL) CYANOMETHYL)-2-METHYLPHENYL)-2-HYDROXY-3, 5-DIIODOBENZAMIDE（ 57808-65-8）：663.07
The Molecular Structure of N-(5-CHLORO-4-((4-CHLOROPHENYL) CYANOMETHYL)-2-METHYLPHENYL)-2-HYDROXY-3, 5-DIIODOBENZAMIDE（ 57808-65-8）is :
Density:1.943 g/cm³
melting point:210 - 220^°C
Boiling point: 590.5 ^°C at 760 mmHg
Flash point: 310.9 ^°C
Solubility in water:Insoluble
Index of Refraction: 1.736
Molar Refractivity: 137 cm³
Polarizability: 54.31 10^-24cm³
Surface Tension: 68.2 dyne/cm
Enthalpy of Vaporization: 91.36 kJ/mol
Vapour Pressure:1.53E-14 mmHg at 25^°C
Appearance:Off white crystalline powder
IUPAC Name: N-[5-chloro-4-[(4-chlorophenyl)-cyano-methyl]-2-methyl-phenyl]-2-hydroxy-3,5-diiodo-benzamide
Synonyms:5-diiodo-y-;benzamide,n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydrox;faskoverm;iodobenzamide;5'-CHLORO-4'-(4-CHLORO-ALPHA-CYANOBENZYL)-3,5-DIIODO-2'-METHYLSALICYLANILIDE;CLOSANTEL;CLOSANTEL BASE;n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-di

Toxicity Data With Reference

1.	orl-rat LD50:262 mg/kg	DCTODJ Drug and Chemical Toxicology. 8 (1985),101.
2.	ims-rat LD50:28,400 µg/kg	DCTODJ Drug and Chemical Toxicology. 8 (1985),101.
3.	orl-mus LD50:331 mg/kg	DCTODJ Drug and Chemical Toxicology. 8 (1985),101.
4.	ims-mus LD50:56,800 µg/kg	DCTODJ Drug and Chemical Toxicology. 8 (1985),101.

Safety Profile

Poison by ingestion and intramuscular routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x, I⁻, and Cl⁻.
Hazard Codes:Xn
Xn:Harmful
Risk Statements
R22:Harmful if swallowed.
RIDADR :2811
RTECS:CV2444250
HazardClass:6.1(b)
PackingGroup:III

Specification

Stable under ordinary conditions