Reference

A comparison of the effects of acute and one year's continuous neuroleptic treatment on the release of [3H]glutamate and [3H]acetylcholine from rat striatal slices

A comparison of the effects of acute and one year's continuous neuroleptic treatment on the release of [3H]glutamate and [3H]acetylcholine from rat striatal slices. Kerwin, R. W.; Rupniak, N. M. J.; Jenner, P.; Marsden, C. D. (Med. Sch., King's Coll. 51-84-3 and 15676-16-1 which are cas registry numbers are also used here. Hosp., London SE5, UK). Neuroscience (Oxford), 11(1), 205-10 (English) 1984. CODEN: NRSCDN. ISSN: 0306-4522. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Acute administration of haloperidol [52-86-8], trifluoperazine [117-89-5], and clozapine [5786-21-0] to rats increased the K-evoked release of acetylcholine [51-84-3] from striatal slices in a dose-dependent fashion, whereas sulpiride [15676-16-1] was without effect. None of the neuroleptics given acutely had any effect on the K-evoked striatal release of glutamate [56-86-0]. K-evoked striatal release of acetylcholine in animals receiving haloperidol, trifluoperazine, or sulpiride for 1 yr was not different from that in age-matched control animals, but was less than controls in animals receiving clozapine for 1 yr. All drugs caused a decrease in K-evoked striatal glutamate release following drug administration for 1 y compared to age-matched controls. The reversal of the acute action of neuroleptic drugs on striatal acetylcholine and glutamate release is consistent with a functional increase in striatal dopamine transmission following long-term neuroleptic treatment. .

Role of biological membranes in psychiatric therapy

Role of biological membranes in psychiatric therapy. Lipcsey, Attila (Fovarosi Janos Korhaz Neuro-Psychiatr. Oszt., Budapest, Hung.). Magy. Tud. Akad. Biol. Tud. Oszt. Kozl., 25(4), 685-95 (Hungarian) 1982. CODEN: MTKZAI. ISSN: 0025-0333. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Addn. of Triton X-100 to a rat brain synaptosome fraction increased the lactic dehydrogenase [9001-60-9] activity and, to a lesser degree, that of glutamic-oxalacetic transaminase [9000-97-9] and aldolase [9024-52-6]. 9000-97-9 and 9001-60-9 which are cas registry numbers are also used here. When phenothiazine [92-84-2] was added to the system in addn. to Triton X-100, the enzymes were inhibited. Phenothiazine by itself inhibited the activity of the enzymes when added at low concns.; high concns., however, caused a time-dependent activation. Frenolon [522-23-6] (1.6 ′ 10-4M) inhibited lactic dehydrogenase by 67%. These findings, together with literature data on Li+, indicate that psychotropics interact with brain membranes. The detn. of the major tranquilizers Hibernal [69-09-0] and Leponex [5786-21-0] in serum by gas chromatog. is described, using a modification of the method of F. A. Vanderheeren (1976). .