CAS No.579-56-6,ISOXSUPRINE HYDROCHLORIDE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	579-56-6
Name:	ISOXSUPRINE HYDROCHLORIDE

Formula:	C₁₈H₂₃NO₃^.HCl
Molecular Weight:	337.846
Synonyms:	Benzenemethanol,4-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-,hydrochloride (9CI);Benzyl alcohol, p-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-,hydrochloride (8CI);Norephedrine, p-hydroxy-N-(1-methyl-2-phenoxyethyl)-,hydrochloride (6CI);1-(p-Hydroxyphenyl)-2-(1'-methyl-2'-phenoxy)ethylaminopropanol-1hydrochloride;Dilavase;Divadilan;Duvadilan;Duviculine;Isolait;Isoxsuprinhydrochloride;Isoxsuprine hydrochloride;Navilox;Suprilent;Suprox SR;Vadosilan;Vasodilan;Vasoplex;Vasotran;
EINECS:	209-443-6
Density:	1.146g/cm3
Melting Point:	203-204°
Boiling Point:	484.2 °C at 760 mmHg
Flash Point:	246.6 °C
Hazard Symbols:	Xn
Risk Codes:	22
Safety:	36
PSA:	61.72000
LogP:	4.06410

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Chemistry

Chemistry informtion about Vasodilan (CAS NO.579-56-6) is:
IUPAC Name: 4-[1-Hydroxy-2-(1-Phenoxypropan-2-Ylamino)Propyl]Phenol Hydrochloride
Synonyms: Isoxsuprine Hcl ; Isoxsuprine Hydrochloride ; 1-(P-Hydroxyphenyl)-2-(1'-Methyl-2'-Phenoxy)Ethylaminopropanol-1hydrochlorid ; 2-(3-Phenoxy-2-Propylamino)-1-(P-Hydroxyphenyl)-1-Propanolhydrochloride ; Isolait ; Isoxsuprinhydrochloride ; P-Hydroxy-Alpha-(1-((1-Methyl-2-Phenoxyethyl)Amino)Ethyl)-Benzylalcohohyd ; Suprilent
MF: C₁₈H₂₄ClNO₃
MW: 337.84
EINECS: 209-443-6
Flash Point: 246.6 °C
Boiling Point: 484.2 °C at 760 mmHg
Vapour Pressure: 3.45E-10 mmHg at 25°C
Enthalpy of Vaporization: 78.94 kJ/mol
Following is the molecular structure of Vasodilan (CAS NO.579-56-6) is:

Uses

Vasodilan (CAS NO.579-56-6) relaxes veins and arteries, which makes them wider and allows blood to pass through them more easily. These actions may help treat the symptoms of conditions such as cerebral vascular insufficiency (poor blood flow to the brain), arteriosclerosis (hardening of the arteries), Raynaud's phenomenon, and other conditions involving poor blood flow in the veins and arteries. It may also be used for purposes other than those listed in this medication guide.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	57mg/kg (57mg/kg)	behavioral: ataxia cardiac: change in rate skin and appendages (skin): "dermatitis, other: after systemic exposure"	Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959.
dog	LD50	oral	> 1200mg/kg (1200mg/kg)	gastrointestinal: nausea or vomiting	Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959.
dog	LD50	subcutaneous	143mg/kg (143mg/kg)		Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959.
mouse	LD50	intraperitoneal	185mg/kg (185mg/kg)	behavioral: excitement lungs, thorax, or respiration: respiratory depression gastrointestinal: changes in structure or function of salivary glands	Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959.
mouse	LD50	intravenous	61mg/kg (61mg/kg)	behavioral: excitement gastrointestinal: changes in structure or function of salivary glands lungs, thorax, or respiration: respiratory depression	Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959.
mouse	LD50	oral	1100mg/kg (1100mg/kg)	behavioral: excitement lungs, thorax, or respiration: respiratory depression gastrointestinal: changes in structure or function of salivary glands	Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959.
mouse	LD50	subcutaneous	1500mg/kg (1500mg/kg)	behavioral: excitement lungs, thorax, or respiration: respiratory depression gastrointestinal: changes in structure or function of salivary glands	Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959.
rat	LD50	intraperitoneal	164mg/kg (164mg/kg)		Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat	LD50	intravenous	77mg/kg (77mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
rat	LD50	oral	1750mg/kg (1750mg/kg)		Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Used as a vasodilator. When heated to decomposition it emits toxic fumes of NO_x and HCl.
Hazard Codes:
Harmful Xn
Risk Statements:
R22:Harmful if swallowed.
Safety Statements:
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: DO8225000