Reference

Cilioinhibitory effect of phenothiazines in vitro and its antagonism by calcium (2+) ion

Cilioinhibitory effect of phenothiazines in vitro and its antagonism by calcium (2+) ion. Adler, K. B.; Fand, I. (Creedmoor Inst. Psychobiol. Stud., Queens Village, N. Y., USA). Arch. Int. Pharmacodyn. Ther., 227(2), 309-23 (English) 1977. CODEN: AIPTAK. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Chlorpromazine (I) [50-53-3] had a greater cilioinhibitory effect than prochlorperazine [58-38-8] on the rotational velocity of tissue explants from the frog palate in amphibian Ringers, and on the frequency of ciliary beating in rat tracheal rings in culture medium. Addn. of Ca acetate in equal molarity to I reversed this inhibition, while dibutyryl cyclic AMP [362-74-3] did not. Simultaneous addn. of Ca and I slowed down, but did not stop, this ciliostasis, while priming with Ca or cyclic AMP prior to drug addn. had less of an effect. These data support the theory that I exerts its actions by displacing Ca from membrane sites.

The prolactin response to neuroleptic drugs

The prolactin response to neuroleptic drugs. A test of dopaminergic blockade: neuroendocrine studies in normal men. Langer, Gerhard; Sachar, Edward J.; Halpern, Frieda S.; Gruen, Peter H.; Solomon, Murray (Dep. Psychiatry, Albert Einstein Coll. Med., Bronx, N. Y., USA). J. Clin. Endocrinol. Metab., 45(5), 996-1002 (English) 1977. CODEN: JCEMAZ. ISSN: 0021-972X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Repeated administrations of haloperidol (I) [52-86-8] (1 mg, i.m.) and prochlorperazine (II) [58-38-8] (4 mg, i.v.) demonstrated a high reproducibility of the prolactin (PRL) [9002-62-4] response within a normal subject. The PRL-response to 4 doses of I, ranging from 0.25 to 1.5 mg, showed a sigmoid dose-response curve. A dose as small as 1.5 mg of I induced maximal PRL response. Dose-PRL response curves of I, II, and thiothixene [5591-45-7], representing 3 chem. classes of neuroleptic drugs, showed a parallel relationship. This suggests a common pharmacol., very likely antidopaminergic, mechanism of the drugs when releasing PRL. In response to I (1 mg), chlorpromazine [50-53-3] (25 mg), and trifluoperazine [117-89-5] (4 mg), plasma PRL concns. remained elevated for at least 7 h, consistent with the reported plasma half-lives of these drugs. Dose equivalencies of 7 neuroleptic drugs in inducing PRL secretion in man are given. Thus the PRL response to neuroleptic drugs is sensitive and reliable and is probably a valid test of dopaminergic blockade in man. These findings suggest a model for studying drug and hormonal interactions with neuroleptics in man.