Reference

Studies on clinical pharmacy

Studies on clinical pharmacy. IX. The urinary excretion of vitamin B6 and its derivatives. Satake, Kenzo; Zaitsu, Naotoshi (Dep. Pharm., Kumamoto Univ. Hosp., Kumamoto, Japan). Kyushu Yakugakkai Kaiho, 30, 91-6 (Japanese) 1976. CODEN: KYYKBN. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 18 Urinary pyridoxic acid (I) was detd. as an index of excretion of vitamin B6 [8059-24-3] after oral administration of various vitamin B6-active compds. in healthy human subjects. Excretion of I was more rapid after administration of pyridoxine-HCl [58-56-0] in combination with drugs for the stomach than after administration of pyridoxine-HCl alone. Excretion of I was greater and more rapid after administration of pyridoxal phosphate [54-47-7] than after that of pyridoxine-HCl. The rate of urinary excretion of I differed depending on the form of prepn. of pyridoxal phosphate. On the other hand, the rate of I excretion after administration of powd. pyridoxamine phosphate [529-96-4] was almost the same as that after administration of enteric coated tablet of pyridoxal phosphate.

Spectrophotometric analysis of pharmaceuticals containing tuberculostatics

Spectrophotometric analysis of pharmaceuticals containing tuberculostatics. Amal, Hayriye; Demir, Serpil (Eczacilik Fak., Univ. Istanbul, Istanbul, Turk.). Istanbul Univ. Eczacilik Fak. Mecm., 11(2), 214-20 (English) 1975. CODEN: IEFMA9. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) A new spectrophotometric method for detg. isoniazid (I) [54-85-3], alone or in binary mixts. with pyridoxine-HCl (II) [58-56-0], thiacetazone (III) [104-06-3], or Ca benzoyl-p-aminosalicylate (IV) [528-96-1], consisted of measuring UV absorbances in water or EtOH. The relative concns. of each component in a binary mixt. of I and II were calcd. by measuring the absorbances at 264 and 278.02 nm and using the appropriate equations. The same procedure was used for calcg. the concns. of I and III in their binary mixts. The wavelengths used were 290 and 249.6 nm. For a binary mixt. of I and IV, the wavelengths chosen were 270 and 315 nm. The results corresponded with the stated quantities of the drugs in the mixts. The measurable amts. were .apprx.2-10 .mu.g for I and II, .apprx.1-3 .mu.g for III, and .apprx.2-8 .mu.g for IV. The method is quick, simple, and reproducible and can be usd for estn. of I, III, and IV in pharmaceutical prepns.