CAS No.58-56-0,Pyridoxine hydrochloride Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	58-56-0
Name:	Pyridoxine hydrochloride
Article Data:	26

Formula:	C₈H₁₁NO₃^.ClH
Molecular Weight:	205.641
Synonyms:	3,4-Pyridinedimethanol,5-hydroxy-6-methyl-, hydrochloride (9CI);Pyridoxol, hydrochloride (7CI,8CI);2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine hydrochloride;4,5-Bis(hydroxymethyl)-2-methylpyridin-3-olhydrochloride;4,5-Bis(hydroxymethyl)-3-hydroxy-2-methylpyridine hydrochloride;5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride;Aderomine hydrochloride;Aderoxin;Aderoxine;Hexabetalin;Hexavibex;Pyridipca;Pyridox;Pyridoxin hydrochloride;Pyridoxine chloride;
EINECS:	200-386-2
Density:	1.2784 (rough estimate)
Melting Point:	214-215 °C(lit.)
Boiling Point:	491.9 °C at 760 mmHg
Flash Point:	251.3 °C
Solubility:	0.1 g/mL at 20 °C in water
Appearance:	Crystalline
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-37/39
PSA:	73.58000
LogP:	0.88220

Synthetic route

: 10030-93-0
pyridoxine triacetate

: 58-56-0
pyridoxal hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water for 2h; Heating;	98%
With hydrogenchloride; water for 2h; Heating / reflux;	72%

: 2397-71-9
5-hydroxy-6-methylpyridine-3,4-dicarboxylic acid diethyl ester

: 58-56-0
pyridoxal hydrochloride

Conditions

Conditions	Yield
Stage #1: 5-hydroxy-6-methylpyridine-3,4-dicarboxylic acid diethyl ester With sodium tetrahydroborate; iron(II) sulfate; N,N-dimethyl-aniline In tetrahydrofuran for 4h; Reflux; Stage #2: With hydrogenchloride In tetrahydrofuran at 20℃; Reagent/catalyst; Solvent;	93.4%

: 4,5-dihydroxymethyl-2-methyl-2-cyclopentenone

: 58-56-0
pyridoxal hydrochloride

Conditions

Conditions	Yield
Stage #1: 4,5-dihydroxymethyl-2-methyl-2-cyclopentenone With ozone In methanol; water at -30℃; for 3h; Stage #2: With ammonia In methanol; water at 20 - 25℃; for 3h; Stage #3: With hydrogenchloride; pyrographite In ethanol at 55 - 60℃; for 1h; Temperature; Solvent;	92%

: 2-hydroxymethyl-3-cyano-4-hydroxy-n-butyraldehyde

: 13515-97-4
methyl 2-aminopropanoate monohydrochloride

: 58-56-0
pyridoxal hydrochloride

Conditions

Conditions	Yield
Stage #1: 2-hydroxymethyl-3-cyano-4-hydroxy-n-butyraldehyde; methyl 2-aminopropanoate monohydrochloride With sodium methylate In methanol at 30 - 50℃; for 5h; Green chemistry; Stage #2: With hydrogenchloride In methanol; water for 2h; Temperature; Solvent; Reagent/catalyst; Reflux; Green chemistry;	90.5%

: 4-methyl-5-dimethyl-tert-butylsiloxyoxazole

: 4469-34-5
2-propyl-4,7-dihydro-2H-1,3-dioxepine

: 58-56-0
pyridoxal hydrochloride

Conditions

Conditions	Yield
Stage #1: 4-methyl-5-dimethyl-tert-butylsiloxyoxazole; 2-propyl-4,7-dihydro-2H-1,3-dioxepine at 115 - 120℃; for 10h; Stage #2: With water In ethanol at 20℃; for 3h; Stage #3: With hydrogenchloride In ethanol; water at 20℃; for 2h;	89.5%

: 5205-63-0
Diels-Alder adduct

: 58-56-0
pyridoxal hydrochloride

Conditions

Conditions	Yield
Stage #1: Diels-Alder adduct With hydrogenchloride In ethanol; water at 20℃; for 2h; Stage #2: In ethanol; water for 2h;	86.05%

: C8H13NO4

: 58-56-0
pyridoxal hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; pyrographite In ethanol; water at 75 - 78℃; for 3h; Temperature;	83.5%

: 4-methyl-5-triisopropylsiloxyoxazole

: 4469-34-5
2-propyl-4,7-dihydro-2H-1,3-dioxepine

: 58-56-0
pyridoxal hydrochloride

Conditions

Conditions	Yield
Stage #1: 4-methyl-5-triisopropylsiloxyoxazole; 2-propyl-4,7-dihydro-2H-1,3-dioxepine at 115 - 120℃; for 10h; Stage #2: With water In ethanol at 20℃; for 3h; Stage #3: With hydrogenchloride In ethanol; water at 20℃; for 2h;	82.7%

: 4469-34-5
2-propyl-4,7-dihydro-2H-1,3-dioxepine

: 24201-52-3
4-methyl-5-butoxy1,3-oxazole

: 58-56-0
pyridoxal hydrochloride

Conditions

Conditions	Yield
Stage #1: 2-propyl-4,7-dihydro-2H-1,3-dioxepine; 4-methyl-5-butoxy1,3-oxazole With calcium oxide at 150℃; for 12h; Diels-Alder Cycloaddition; Stage #2: With hydrogenchloride In ethanol; water at 20 - 60℃; for 12h; Stage #3: With hydrogenchloride In water for 1h; pH=8; Reagent/catalyst; Reflux;	80%

: 5006-20-2
5-ethoxy-4-methyl-oxazole

: 4469-34-5
2-propyl-4,7-dihydro-2H-1,3-dioxepine

: 58-56-0
pyridoxal hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride Diels-Alder Cycloaddition;	78.5%

Raw Materials

108-31-6

Downstream Products

94-75-7

54-47-7

529-96-4

10030-93-0

524-36-7

948-00-5

66-72-8

447-05-2

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Chemistry

IUPAC Name: 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
Molecular Formula: C₈H₁₂ClNO₃
Molecular Weight: 205.64 g/mol
SMILES: c1(c(cnc(c1O)C)CO)CO.Cl
InChI: InChI=1/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H
EINECS: 200-386-2
Classification Code: Drug / Therapeutic Agent; Human Data; Mutation data; Reproductive Effect; Vitamin [enzyme co-factor]
Product Categories: Biochemistry; Pyridinium Compounds; Vitamins; Nutritional Supplements; Vitamins and derivatives; Aromatics; Heterocycles; Vitamin Ingredients
Flash Point: 251.3 °C
Enthalpy of Vaporization: 79.91 kJ/mol
Boiling Point: 491.9 °C at 760 mmHg
Melting Point: 214-215 °C(lit.)
storage temperature: 2-8 °C
solubility: H₂O: 0.1 g/mL at 20 °C, clear, colorless
Sensitive: Light Sensitive
Stability: Stable. Protect from air and light.
Vapour Pressure of Pyridoxine hydrochloride (CAS NO.58-56-0): 1.71E-10 mmHg at 25 °C

Uses

Pyridoxine hydrochloride (CAS NO.58-56-0) is widely used in pharmaceutical ,food and feed additives and also could be used in the cosmetics .

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	intramuscular	500mg/kg (500mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
cat	LD50	intravenous	560mg/kg (560mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
cat	LD50	oral	1gm/kg (1000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
dog	LD50	oral	> 500mg/kg (500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
mouse	LD50	intravenous	660mg/kg (660mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
mouse	LD50	oral	5500mg/kg (5500mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
mouse	LD50	subcutaneous	2450mg/kg (2450mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
pigeon	LD50	intravenous	145mg/kg (145mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
rabbit	LD50	intravenous	464mg/kg (464mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
rat	LD50	intravenous	530mg/kg (530mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
rat	LD50	oral	4gm/kg (4000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
rat	LD50	subcutaneous	3gm/kg (3000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS of Pyridoxine hydrochloride (CAS NO.58-56-0): UV1350000

Specification

Pyridoxine hydrochloride (CAS NO.58-56-0), its Synonyms are 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride ; 5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride ; Vitamin B6 hydrochloride ; 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine hydrochloride ; 3-Hydroxy-4,5-dihydroxymethyl-2-methylpyridine hydrochloride ; 3-Hydroxy-4,5-dimethylol-alpha-picoline hydrochloride ; 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride ; Aderomine hydrochloride ; 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride (1:1) . It is crystalline.