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CAS No.: | 58-71-9 |
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Name: | Cephalothin |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C16H15N2NaO6S2 |
Molecular Weight: | 418.427 |
Synonyms: | 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-, monosodium salt,(6R-trans)-;Averon 1;Cefalothine sodium;Cemastin;Cephalothin sodium salt;Cephation;Ceporacin;Cepovenin;Coaxin;Keflin;Lilly 38253;Lospoven;Microtin;Seffin;Sodium(thienylacetamido)cephalosporanate;Sodium 3-acetoxymethyl-7b-(2-thienylacetamido)ceph-3-em-4-carboxylate;Sodium 7-(2-thienylacetamido)-3-acetoxymethyl-3-cephem-4-carboxylate;Sodium7-[2-(2-thienyl)acetamido]cephalosporanate;Sodium cefalotin;Sodiumcephalothin;Sodium cephalotin;Synclotin;Toricelocin; |
EINECS: | 200-394-6 |
Melting Point: | 240 °C |
Boiling Point: | 757.2 °C at 760 mmHg |
Flash Point: | 411.8 °C |
Solubility: | water: 50 mg/mL |
Appearance: | Crystalline |
Hazard Symbols: | Xn, Xi |
Risk Codes: | 42/43 |
Safety: | 22-36/37 |
PSA: | 169.38000 |
LogP: | -0.41360 |
Conditions | Yield |
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With sodium 2-ethylhexanoic acid In acetone | 26% |
Conditions | Yield |
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With sodium hydrogencarbonate; sodium 2-ethylhexanoic acid In water; acetone at 0 - 5℃; for 0.5h; |
Conditions | Yield |
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In ethyl acetate; N,N-dimethyl-formamide | 96% |
Conditions | Yield |
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With sodium hydroxide In water at 65℃; for 6h; pH=7; | 89% |
sodium cephalothin
Conditions | Yield |
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With hydrogenchloride; sodium hydrogencarbonate In ice-water; water | 87.5% |
Conditions | Yield |
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In water; butan-1-ol at 20℃; for 48h; | 83% |
Conditions | Yield |
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Stage #1: sodium cephalothin With sodium hydroxide In water at -20 - -10℃; for 0.0375h; Stage #2: With hydrogenchloride In water pH=1.5; cooling; Further stages.; | 80% |
Conditions | Yield |
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With water at 20℃; for 6h; | 72% |
Conditions | Yield |
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With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane; water at 20 - 25℃; for 0.5h; Title compound not separated from byproducts; | A n/a B 62% |
sodium cephalothin
allyl bromide
allyl 7β-(2-(thien-2-yl)acetamido)-3-(acetoxymethyl)-3-cephem-4-carboxylate
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide | 51% |
In water; N,N-dimethyl-formamide for 48h; Ambient temperature; | 48% |
In water; N,N-dimethyl-formamide at 20℃; for 48h; | 41% |
In water; N,N-dimethyl-formamide at 20℃; for 48h; | 41% |
In water; N,N-dimethyl-formamide at 20℃; for 48h; | 41% |
Name : Cefalotin sodium
Synonyms Cephalothin sodium; Sodium cephalothin; Synclotin; 7-(Thiophene-2-acetamido)cephalosporanic acid sodium salt; Monosodium (6R,7R)-3-acetoxymethyl-8-oxo-7-[2-(thiophen-2-yl)acetylamido]-5-thia-1-azabicyclo[4.2.0.]oct-2-ene-2-carboxylate
Molecular:Structure:
Molecular Formula:C16H15N2NaO6S2
Molecular Weight:418.41
EINECS:200-394-6
Merck:13,1994
Molecular Formula:240°C
solubility:H2O: 50 mg/mL, clear, faintly yellow
Water Solubility:158 mg/L
storage temp.:2-8°C
Appearance:Crystalline
1. | ivn-wmn TDLo:20 mg/kg:BLD | AIMEAS Annals of Internal Medicine. 77 (1972),401. | ||
2. | ims-chd TDLo:89 mg/kg/19D-I:BLD AACHAX -,272,63 | |||
3. | ims-man TDLo:955 mg/kg/22D-I:BLD AACHAX -,272,63 | |||
4. | ipr-rat LD50:7000 mg/kg | JJANAX Japanese Journal of Antibiotics. 28 (1975),188. | ||
5. | scu-rat LD50:7500 mg/kg | JIDIAQ Journal of Infectious Diseases. 137 (1978),S51. | ||
6. | ipr-mus LD50:5670 mg/kg | JJANAX Japanese Journal of Antibiotics. 27 (1974),746. | ||
7. | scu-mus LD50:7500 mg/kg | JACHDX Journal of Antimicrobial Chemotherapy. 6 (Suppl A),(1980),79. | ||
8. | ivn-mus LD50:4800 mg/kg | JJANAX Japanese Journal of Antibiotics. 27 (1974),746. |
Human systemic effects by intravenous and intramuscular routes: blood agranulocytosis and thrombocytopenia. When heated to decomposition it emits very toxic fumes of NOx, SOx, and Na2O.
Risk Statements:42/43: May cause sensitization by inhalation and skin contact
Safety Statements:22: Do not breathe dust;36/37: Wear suitable protective clothing and gloves
Hazard Codes:Xn,Xi
WGK Germany:2