Detail of "58-72-0"

Reference

Binding of polynuclear aromatic hydrocarbons to the rat 4S cytosolic binding protein: structure-activity relationships

Binding of polynuclear aromatic hydrocarbons to the rat 4S cytosolic binding protein: structure-activity relationships. Kamps, C.; Safe, S. (Dep. Vet. Physiol., Texas A and M Univ., College Station, TX 77843, USA). Cancer Lett. (Shannon, Irel.Some commonly used reagents like 313-74-6 and 9037-52-9 are used in this experiment.), 34(2), 129-37 (English) 1987. CODEN: CALEDQ. ISSN: 0304-3835. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The relative competitive binding affinities of benzo[a]pyrene (B[a]P)(I) [50-32-8], benzo[e]pyrene [192-97-2], benzo[g,h,i]perylene [191-24-2], picene [213-46-7], 1,12-dimethylbenz[a]anthracene [313-74-6], 1,2,3,4-dibenz[a]anthracene [215-58-7], 1,2,5,6-dibenz[a]anthracene [53-70-3], perylene [198-55-0], 4H-cyclopenta[d,e,f]phenanthrene [203-64-5], benz[a]anthracene [56-55-3], triphenylethylene [58-72-0], and triptycene [477-75-8] for the rat hepatic cytosolic 4S binding protein were detd. using [3H]-I as the radioligand. With the exception of triphenylethylene, triptycene and 4H-cyclopenta[d,e,f]phenanthrene, the median effective concn. (EC50) values for the remainder of these compds. were between 1.25 ′ 10-7 and 2.5 ′ 10-8M with 1,2,5,6-dibenz[a]anthracene being the most active ligand. A comparison of the relative cytosolic Ah (9S) receptor binding affinities and aryl hydrocarbon hydroxylase (AHH) [9037-52-9] induction potencies of these hydrocarbons with their 4S protein binding affinities demonstrated the following: (a) 5 compds., namely 1,2,5,6-dibenz[a]anthracene, 1,2,3,4-dibenz[a]anthracene, picene, I and 3-methylcholanthrene exhibited high to moderate binding affinities for the 4S and 9S cytosolic protein (EC50 values <10-6M) and induced AHH in rat hepatoma cells; (b) compds., namely perylene, benzo[e]pyrene, and benzo[g,h,i]perylene exhibited high affinities for the 4S binding protein (1.25 ′ 10-7, 4.4 ′ 10-8 and 2.9 ′ 10-8M, resp.) and low affinities (EC50 values > 10-5) for the Ah receptor protein; and (c) moreover these 3 compds. did not induced AHH in rat hepatoma H-4-II E cell in culture. The 4S binding protein may not play a significant role in AHH induction although the results do not rule out a function for this protein in the transregulation of AHH and its assocd. cytochromes P 450. .

Model reaction pathways in Kraft lignin pyrolysis

Model reaction pathways in Kraft lignin pyrolysis. Petrocelli, Francis P.; Klein, Michael T. (Dep. Chem.Chemicals with cas numbers 103-29-7 and 103-30-0 also play role. Eng., Univ. Delaware, Newark, DE 19711, USA). Macromolecules, 17(2), 161-9 (English) 1984. CODEN: MAMOBX. ISSN: 0024-9297. DOCUMENT TYPE: Journal CA Section: 43 (Cellulose, Lignin, Paper, and Other Wood Products) Section cross-reference(s): 22, 67 The pyrolysis of Kraft lignin [8068-05-1] was analyzed on the basis of that of model compds. Five 1st-order paths for PhCH2CH2Ph [103-29-7] pyrolysis were found, the most important of which yielded PhMe. Pyrolysis of cis- [645-49-8] or trans-stilbene [103-30-0] was equiv. to that of a near-equil. mixt. in which trans predominated. Pyrolysis of Ph2CH2 [101-81-5] gave C6H6, PhMe, and fluorene; and that of Ph2C:CHPh [58-72-0] gave these plus Ph2CH2, PhCH2CH2Ph, stilbene, and phenanthrene. The Arrhenius parameters for all pathways were detd. Mechanisms for the formation of methylphenols and polycyclic phenols in the pyrolysis of Kraft lignin were developed. .